(RS)-AMPA
- CAS NO.:77521-29-0
- Empirical Formula: C7H10N2O4
- Molecular Weight: 186.17
- MDL number: MFCD00069214
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is (RS)-AMPA?
Chemical properties
White-to-Off White Powder
The Uses of (RS)-AMPA
A potent and selective agonist of the excitatory neurotransmitter L-glutamic Acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists
The Uses of (RS)-AMPA
AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Because AMPA does not interfere with binding sites for kainic acid or NMDA , it can be used to distinguish AMPA receptor-specific activity that contributes to a neuronal response. (R,S)-AMPA contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.
Definition
ChEBI: (S)-AMPA is a non-proteinogenic alpha-amino acid.
Biological Activity
More water soluble hydrobromide salt of ( RS )-AMPA ((RS)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid ).
storage
Room temperature
Properties of (RS)-AMPA
Melting point: | 240 °C |
Density | 1.386±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | H2O: 1.2 mg/mL |
pka | 2.15±0.10(Predicted) |
form | solid |
color | white |
Water Solubility | Soluble in water (10mM, gentle warming) |
Stability: | Hygroscopic |
CAS DataBase Reference | 77521-29-0 |
EPA Substance Registry System | .alpha.-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (77521-29-0) |
Safety information for (RS)-AMPA
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for (RS)-AMPA
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