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HomeProduct name list(RS)-AMPA

(RS)-AMPA

(RS)-AMPA Structural

What is (RS)-AMPA?

Chemical properties

White-to-Off White Powder

The Uses of (RS)-AMPA

A potent and selective agonist of the excitatory neurotransmitter L-glutamic Acid. AMPA does not interfere with binding sites for kainic acid in vitro, and AMPA- induced neuronal excitation is not significantly affected by NMDA antagonists

The Uses of (RS)-AMPA

AMPA is the defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission. Because AMPA does not interfere with binding sites for kainic acid or NMDA , it can be used to distinguish AMPA receptor-specific activity that contributes to a neuronal response. (R,S)-AMPA contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer.

Definition

ChEBI: (S)-AMPA is a non-proteinogenic alpha-amino acid.

Biological Activity

More water soluble hydrobromide salt of ( RS )-AMPA ((RS)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionicacid ).

storage

Room temperature

Properties of (RS)-AMPA

Melting point: 240 °C
Density  1.386±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  H2O: 1.2 mg/mL
pka 2.15±0.10(Predicted)
form  solid
color  white
Water Solubility  Soluble in water (10mM, gentle warming)
Stability: Hygroscopic
CAS DataBase Reference 77521-29-0
EPA Substance Registry System .alpha.-Amino-2,3-dihydro-5-methyl-3-oxo-4-isoxazolepropanoic acid (77521-29-0)

Safety information for (RS)-AMPA

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for (RS)-AMPA

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