CNQX
Synonym(s):6-Cyano-7-nitroquinoxaline-2,3-dione;6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt hydrate;6-Cyano-7-nitroquinoxaline-2,3-dione, 6-Cyano-2,3-dihydroxy-7-nitro-quinoxaline;CNQX - CAS 115066-14-3 - Calbiochem;FG-9065
- CAS NO.：115066-14-3
- Empirical Formula: C9H4N4O4
- Molecular Weight: 232.15
- MDL number: MFCD00069232
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is CNQX?
Chemical properties
Pale Yellow Solid
The Uses of CNQX
A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively
The Uses of CNQX
CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors). This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors.
The Uses of CNQX
CNQX disodium salt hydrate has been used as:
- as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)
- as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)
- as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112)
Definition
ChEBI: 6-Cyano-7-nitroquinoxaline-2,3-dione is a quinoxaline derivative.
Biological Activity
Potent AMPA/kainate receptor antagonist. Also antagonist at glycine modulatory site on NMDA receptor complex.
Biochem/physiol Actions
Potent, competitive AMPA/kainate glutamate receptor antagonist.
storage
Room temperature
Properties of CNQX
| Melting point: | 300 °C |
| Boiling point: | 374.31°C (rough estimate) |
| Density | 1.5507 (rough estimate) |
| RTECS | VD1520000 |
| refractive index | 1.6590 (estimate) |
| storage temp. | protect from light |
| solubility | H2O: 10 mg/mL |
| form | solid |
| pka | 8.16±0.20(Predicted) |
| color | orange to red |
| Stability: | Store Tightly Sealed at RT |
| CAS DataBase Reference | 115066-14-3(CAS DataBase Reference) |
Safety information for CNQX
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for CNQX
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