NBQX DISODIUM SALT

Synonym(s):1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate;1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate;FG 9202;FG 9202 disodium salt hydrate

CAS NO.：118876-58-7
Empirical Formula: C12H8N4O6S
Molecular Weight: 336.28
MDL number: MFCD00274065
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is NBQX DISODIUM SALT?

Chemical properties

Yellow Crystalline Solid

The Uses of NBQX DISODIUM SALT

NBQX disodium salt hydrate has been used:

in N-methyl-D-aspartate receptor (NMDAR) kinetic studies
as an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neurons
in the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSC_NMDAR)

The Uses of NBQX DISODIUM SALT

A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.

Definition

ChEBI: 2,3-Dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline is a member of naphthalenes and a sulfonic acid derivative.

General Description

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.

Biological Activity

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset™ .

Biochem/physiol Actions

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.

storage

Room temperature

Properties of NBQX DISODIUM SALT

Melting point:	361°C
Density	1.6027 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Inert atmosphere,2-8°C
solubility	methanol: 0.25 mg/mL
form	solid
pka	7.55±0.20(Predicted)
color	yellow
Stability:	Freezer at -20°C

Safety information for NBQX DISODIUM SALT

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.