(S)-AMPA

Synonym(s):(S)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid

CAS NO.：83643-88-3
Empirical Formula: C7H10N2O4
Molecular Weight: 186.17
MDL number: MFCD00672630
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-28 23:16:16

What is (S)-AMPA?

The Uses of (S)-AMPA

(S)-AMPA is an analogue for AMPA (A611500) a specific agonist for the AMPA receptor which mimics the glutamate receptor.

The Uses of (S)-AMPA

Active enantiomer of AMPA that induces apoptosis in cortical neurons

The Uses of (S)-AMPA

(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.

What are the applications of Application

(S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid is an active isomer of AMPA with no NMDAR activity

General Description

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).

Biological Activity

Active enantiomer of AMPA (EC 50 = 3.5 μ M). Also available as part of the AMPA Receptor Tocriset™ .

Biochem/physiol Actions

Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.

storage

Room temperature

Properties of (S)-AMPA

alpha	D28 -21 ±2° (c = 0.19 in water)
Density	1.386±0.06 g/cm3(Predicted)
storage temp.	Store at RT
form	White to off-white powder.
pka	2.15±0.10(Predicted)
color	White
Water Solubility	Soluble to 100 mM in water
CAS DataBase Reference	83643-88-3(CAS DataBase Reference)