(S)-AMPA
Synonym(s):(S)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid
- CAS NO.:83643-88-3
- Empirical Formula: C7H10N2O4
- Molecular Weight: 186.17
- MDL number: MFCD00672630
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is (S)-AMPA?
The Uses of (S)-AMPA
(S)-AMPA is an analogue for AMPA (A611500) a specific agonist for the AMPA receptor which mimics the glutamate receptor.
The Uses of (S)-AMPA
Active enantiomer of AMPA that induces apoptosis in cortical neurons
The Uses of (S)-AMPA
(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.
What are the applications of Application
(S)-a-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid is an active isomer of AMPA with no NMDAR activity
General Description
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).
Biological Activity
Active enantiomer of AMPA (EC 50 = 3.5 μ M). Also available as part of the AMPA Receptor Tocriset™ .
Biochem/physiol Actions
Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.
storage
Room temperature
Properties of (S)-AMPA
alpha | D28 -21 ±2° (c = 0.19 in water) |
Density | 1.386±0.06 g/cm3(Predicted) |
storage temp. | Store at RT |
form | White to off-white powder. |
pka | 2.15±0.10(Predicted) |
color | White |
Water Solubility | Soluble to 100 mM in water |
CAS DataBase Reference | 83643-88-3(CAS DataBase Reference) |
Safety information for (S)-AMPA
Computed Descriptors for (S)-AMPA
New Products
Tubulysin H Tubulysin G 2,2-diethoxyethanethioamide Tubulysin D 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 4,4-DIFLUOROPIPERIDINE CYCLOBUTYLAMINE HYDROCHLORIDE 1-(1,1-Difluoroethyl)-2-fluorobenzene 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 2,2-Difluoropropanol 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Imeglimin Hydrochloride IH Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH Magnesium Trisilicate Lubiprostone Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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