Formoterol fumarate dihydrate
Synonym(s):(R*,R*)-N-[2-Hydroxy-5-[1-hydroxy-2-[[2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]phenyl]formamide fumarate;Formoterol hemifumarate salt monohydrate
- CAS NO.:183814-30-4
- Empirical Formula: C23H28N2O8
- Molecular Weight: 460.48
- MDL number: MFCD11045919
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-04-15 18:41:30
What is Formoterol fumarate dihydrate?
Chemical properties
Pale Yellow Solid
The Uses of Formoterol fumarate dihydrate
A selective β2-adrenergic receptor agonist. Used as an antiasthmatic.
The Uses of Formoterol fumarate dihydrate
ForMoterol FuMarate Dihydrate is a selective β2-adrenergic receptor agonist,it is used as an antiasthmatic.
The Uses of Formoterol fumarate dihydrate
Formoterol is a selective β2-adrenergic receptor agonist. Formoterol is used as an antiasthmatic.
Biological Activity
Potent, selective and long-acting β 2 -adrenoceptor agonist. Displays 330-fold selectivity for β 2 over β 1 receptors (pK d values are 8.12 and 5.58 respectively). Potently relaxes guinea pig trachea (pD 2 = 9.29), and is longer-acting and 100-fold more potent than salbutamol.
Biochem/physiol Actions
β2-Adrenoreceptor agonist.
Drug interactions
The efficacy and tolerability of glycopyrronium/formoterol fumarate metered dose inhaler, a fixed-dose combination of glycopyrronium/formoterol fumarate dihydrate 14.4/10 μg (equivalent to glycopyrrolate/formoterol fumarate 18/9.6 μg) delivered by metered dose inhaler using innovative co-suspension delivery technology, was investigated in patients (n = 292) with COPD [12C]. There were no meaningful pharmacokinetic interactions, whether drug–drug or due to formulation, between glycopyrronium and formoterol following treatment with formulated using a new co-suspension delivery technology. The incidence of cardiovascular events of special interest was low (stroke, 0%–0.4%; cardiac ischemia, 0.4%–2.3%; cardiac failure, 1.3%–2.5%; arrhythmia, 1.3%–3.2%), and no important trends in clinical laboratory results, vital signs, or electrocardiograms were observed[1].
References
[1] Aagaard, Lise . "A worldwide yearly survey of new data in adverse drug reactions." (2014).
Properties of Formoterol fumarate dihydrate
Melting point: | 116-120°C |
storage temp. | 2-8°C |
solubility | DMSO: soluble20mg/mL |
form | solid |
color | white to off-white |
CAS DataBase Reference | 183814-30-4 |
Safety information for Formoterol fumarate dihydrate
Signal word | Danger |
Pictogram(s) |
Exclamation Mark Irritant GHS07 Health Hazard GHS08 |
GHS Hazard Statements |
H332:Acute toxicity,inhalation H370:Specific target organ toxicity, single exposure H373:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P201:Obtain special instructions before use. P202:Do not handle until all safety precautions have been read and understood. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. |
Computed Descriptors for Formoterol fumarate dihydrate
InChIKey | RATSWNOMCHFQGJ-XODSYJLDSA-N |
SMILES | C(/C(=O)O)=C\C(=O)O.[C@@H](C1C=CC(O)=C(NC=O)C=1)(O)CN[C@@H](C)CC1C=CC(OC)=CC=1 |&1:8,22,r| |
Abamectin manufacturer
Vamsi Labs Ltd
Ralington Pharma
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