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HomeProduct name listRoxatidine

Roxatidine

Roxatidine Structural

What is Roxatidine?

Description

Roxatidine (78273-80-0) is a novel histamine H2 receptor antagonist.1?Suppresses inflammatory responses via inhibition of NFκB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages.2?Clinically useful agent for prevention and healing of gastric and duodenal ulcers and bleeding.3?Attenuates degradation of extracellular matrix in osteoarthritis models by inactivating the NFkB pathway.4

The Uses of Roxatidine

Anti-ulcerative.

References

1) Mills and Wood (1989),?The pharmacology of histamine H2-receptor antagonists; Methods Find. Exp. Clin. Pharmacol., 11 Suppl. 1?87 2) Cho?et al. (2011), Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages; J. Cell. Biochem.,?112?3648 3) Imaeda?et al.?(2011),?Effect of lansoprazole versus roxatidine on prevention of bleeding and promotion of ulcer healing after endoscopic submucosal dissection for superficial gastric neoplasia; J. Gastroenterol.,?46?1267 4) Ze?et al. (2017),?Roxatidine Attenuates Degradation of Extracellular Matrix;?Biomed. Pharmacother.,?95?1156

Properties of Roxatidine

Melting point: 59-60 °C
Boiling point: 524.3±45.0 °C(Predicted)
Density  1.137±0.06 g/cm3(Predicted)
storage temp.  -20°
solubility  Soluble in DMSO (up to 25 mg/ml).
form  oil
pka 13.34±0.10(Predicted)
color  Colorless to pale yellow
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
CAS DataBase Reference 78273-80-0(CAS DataBase Reference)

Safety information for Roxatidine

Computed Descriptors for Roxatidine

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