Rosiptor

CAS NO.：782487-28-9
Empirical Formula: C20H35NO2
Molecular Weight: 321.5
MDL number: MFCD31619271
EINECS: 200-001-8
Update Date: 2024-10-14 18:20:50

What is Rosiptor?

Description

Rosiptor (AQX-1125) is a selective and orally active phosphatase SHIP1 activator with anti-inflammatory effects. It inhibits Akt phosphorylation, inflammatory mediator production and leukocyte chemotaxis in vitro.

The Uses of Rosiptor

Rosiptor has been used in trials studying the treatment of COPD, Atopic Dermatitis, Interstitial Cystitis, and Bladder Pain Syndrome.

Biological Activity

Rosiptor is a small-molecule SHIP1 activator.The activating effect of Rosiptor on SHIP1 is 28% at 100 μM in the native enzyme but no effect of Rosiptor is observed when the SHIP1δC2 enzyme is used. Rosiptor induces a concentration-dependent decrease in Akt phosphorylation in MOLT-4 cells, while it fails to affect Akt phosphorylation in Jurkat cells. At 0.1 μM Rosiptor the inhibition amounts to an average of 34%, while at 10 μM the inhibition amounts to an average of 82% in two independent experiments. Rosiptor also induces a concentration-dependent decrease in the production of multiple pro-inflammatory mediators in this system, without affecting cell viability. Rosiptor dose dependently inhibits chemotaxis of most cell types at low micromolar concentrations independent of the chemotactic stimulus.

Properties of Rosiptor

Boiling point:	451.6±45.0 °C(Predicted)
Density	1.07±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 150 mg/mL (466.56 mM)
pka	15.05±0.10(Predicted)
form	Solid
color	White to off-white
InChI	InChI=1S/C20H35NO2/c1-13-4-5-17-16(11-21)18(7-9-19(13,17)2)20(3)8-6-15(23)10-14(20)12-22/h14-18,22-23H,1,4-12,21H2,2-3H3/t14-,15+,16+,17+,18+,19-,20+/m1/s1