Ropinirole hydrochloride
Synonym(s):4-[2-(Dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one hydrochloride;Ropinirole hydrochloride;SKF 101468 hydrochloride
- CAS NO.：91374-20-8
- Empirical Formula: C16H25ClN2O
- Molecular Weight: 296.84
- MDL number: MFCD01754173
- EINECS: 635-615-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-22 17:12:53
What is Ropinirole hydrochloride?
Description
ReQuip was launched in the UK as a monotherapy or in combination with low-dose levodopa for the treatment of early-stage idiopathic Parkinson's disease. An eight step (24% overall yield) synthesis from isochroman provides access to ropinirole. It is a non-ergot postsynaptic dopamine D2 agonist with activity in the extrapyramidal system. It has weak or no significant activity at α2-adrenergic, 5-HT2 receptors and is inactive at 5-HT1, benzodiazepine, GABA, α1 and β adrenoreceptors. Thus it has essentially no CNS side effects, fewer dyskinesias and on-off fluctuations. In animals, it was able to reverse all motor deficits induced by MPTP. Tolerance is not developed and ropinirole has similar postsynaptic potency to apomorphine but with significantly less stereotyped behavior.
The Uses of Ropinirole hydrochloride
An antiparkinsonian agent. A selective dopamine D2-receptor agonist
What are the applications of Application
Ropinirole Hydrochloride is a dopamine receptor agonist
Properties of Ropinirole hydrochloride
| Melting point: | 241-243°C |
| storage temp. | 2-8°C |
| solubility | H2O: >10mg/mL |
| form | powder |
| color | light yellow |
Safety information for Ropinirole hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Environment GHS09 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H400:Hazardous to the aquatic environment, acute hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. |
Computed Descriptors for Ropinirole hydrochloride
Abamectin manufacturer
Dr. Reddy's Laboratories Ltd
Synthokem Labs Private Limited
SVK Laboratories Pvt Ltd
Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.)
Rivashaa Agrotech Biopharma Pvt. Ltd.
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