Rimantadine hydrochloride
Synonym(s):α-Methyltricyclo[3.3.1.13,7]-decane-1-methanamine hydrochloride;1-(1-Adamantyl)ethylamine hydrochloride;Rimantadine hydrochloride
- CAS NO.：1501-84-4
- Empirical Formula: C12H21N.ClH
- Molecular Weight: 215.76
- MDL number: MFCD00072023
- EINECS: 604-725-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
What is Rimantadine hydrochloride?
Description
Rimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile.
Chemical properties
White Crystalline Solid
Originator
DuPont (USA)
The Uses of Rimantadine hydrochloride
Rimantadine Hydrochloride is used as an antiviral agent.
What are the applications of Application
Rimantadine Hydrochloride is an antiviral compound
Definition
ChEBI: Rimantadine hydrochloride is an organic molecular entity.
brand name
Flumadine (Forest);Roflual.
References
[1] koff w c, elm jr j l, halstead s b. suppression of dengue virus replication in vitro by rimantadine hydrochloride[j]. the american journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] koff w c, peavy d l, knight v. inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[j]. infection and immunity, 1979, 23(3): 665-669.
[3] hayden f g, monto a s. oral rimantadine hydrochloride therapy of influenza a virus h3n2 subtype infection in adults[j]. antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.
Properties of Rimantadine hydrochloride
| Melting point: | >300 °C(lit.) |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly), Water(Slightly) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Freely soluble in water. |
| Merck | 14,8224 |
| InChI | InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H |
| CAS DataBase Reference | 1501-84-4 |
Safety information for Rimantadine hydrochloride
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Rimantadine hydrochloride
| InChIKey | OZBDFBJXRJWNAV-UHFFFAOYSA-N |
| SMILES | C1C2CC3(C(N)C)CC1CC(C3)C2.Cl |
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