Rimantadine hydrochloride

Synonym(s):α-Methyltricyclo[3.3.1.1³,⁷]-decane-1-methanamine hydrochloride;1-(1-Adamantyl)ethylamine hydrochloride;Rimantadine hydrochloride

CAS NO.：1501-84-4
Empirical Formula: C12H21N.ClH
Molecular Weight: 215.76
MDL number: MFCD00072023
EINECS: 604-725-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-03-26 14:13:49

What is Rimantadine hydrochloride?

Description

Rimantadine hydrochloride is an antiviral analogue of amantadine, reportedly useful in the prophylaxis and treatment of influenza A. Compared with amantadine, nmantadine appears to have a lower side-effect profile.

Chemical properties

White Crystalline Solid

Originator

DuPont (USA)

The Uses of Rimantadine hydrochloride

Rimantadine Hydrochloride is used as an antiviral agent.

What are the applications of Application

Rimantadine Hydrochloride is an antiviral compound

Definition

ChEBI: Rimantadine hydrochloride is an organic molecular entity.

brand name

Flumadine (Forest);Roflual.

References

[1] koff w c, elm jr j l, halstead s b. suppression of dengue virus replication in vitro by rimantadine hydrochloride[j]. the american journal of tropical medicine and hygiene, 1981, 30(1): 184-189.
[2] koff w c, peavy d l, knight v. inhibition of in vitro proliferative responses of human lymphocytes by rimantadine hydrochloride[j]. infection and immunity, 1979, 23(3): 665-669.
[3] hayden f g, monto a s. oral rimantadine hydrochloride therapy of influenza a virus h3n2 subtype infection in adults[j]. antimicrobial agents and chemotherapy, 1986, 29(2): 339-341.

Properties of Rimantadine hydrochloride

Melting point:	>300 °C(lit.)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly), Water(Slightly)
form	Solid
color	White to Off-White
Water Solubility	Freely soluble in water.
Merck	14,8224
InChI	InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H
CAS DataBase Reference	1501-84-4

Safety information for Rimantadine hydrochloride

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.