Emodin
Synonym(s):Emodin;Archin;Rheum emodin;Emodol;Frangula-emodin
- CAS NO.:518-82-1
- Empirical Formula: C15H10O5
- Molecular Weight: 270.24
- MDL number: MFCD00001207
- EINECS: 208-258-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:07:02
What is Emodin?
Chemical properties
red-orange powder
The Uses of Emodin
Emodin has been used:
- to investigate its regulatory mechanisms on lipopolysaccharide (LPS)-induced inflammatory injury in myocarditis
- as a reference standard for the development and validation of high performance liquid chromatography (HPLC)-photodiode array (PDA) assay method
- to inhibit Tau aggregation
- for direct binding assay
The Uses of Emodin
Occurs mostly as the rhamnoside (see Frangulin) in rhubarb root. Cathartic.
The Uses of Emodin
antibacterial, antineoplastic, cathartic, tyrosine kinase inhibitor
What are the applications of Application
Emodin is a potent Lck tyrosine kinase inhibitor shown to suppress Neu tyrosine kinase activity
Definition
ChEBI: Emodin is a trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs. It has a role as a tyrosine kinase inhibitor, an antineoplastic agent, a laxative and a plant metabolite. It is functionally related to an emodin anthrone. It is a conjugate acid of an emodin(1-).
General Description
Orange needles or powder.
Air & Water Reactions
Insoluble in water.
Reactivity Profile
Emodin may be sensitive to prolonged exposure to light. Probably a weak acid due to the phenolic functional groups.
Health Hazard
ACUTE/CHRONIC HAZARDS: When heated to decomposition Emodin emits acrid smoke and irritating fumes.
Fire Hazard
Flash point data for Emodin are not available; however, Emodin is probably combustible.
Biological Activity
Naturally occurring anthraquinone that displays a range of biological activities. Exhibits anti-inflammatory, antitumor and neuroprotective effects.
Biochem/physiol Actions
Cell permeable: yes
Purification Methods
Archin forms orange needles from EtOH, Et2O, *C6H6, toluene or pyridine. It sublimes above 200o at 12mm. [Tutin & Clewer J Chem Soc 99 946 1911, IR: Bloom et al. J Chem Soc 178 1959, UV: Birkinshaw Biochem J 59 495 1955, Raistrick Biochem J 34 159 1940.] 1R,2S-(-)Ephedrine see (-)-ephedrine (1R,2S-2-methylamino-1-phenylpropanol) in “Miscellaneous” in Chapter 6.
Properties of Emodin
Melting point: | 255 °C (dec.)(lit.) |
Boiling point: | 373.35°C (rough estimate) |
Density | 1.3280 (rough estimate) |
refractive index | 1.5000 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO: soluble |
pka | 6.39±0.20(Predicted) |
form | powder |
color | orange |
Water Solubility | <0.1 g/100 mL at 19 ºC |
Merck | 14,3561 |
BRN | 1888141 |
CAS DataBase Reference | 518-82-1(CAS DataBase Reference) |
EPA Substance Registry System | Emodin (518-82-1) |
Safety information for Emodin
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P501:Dispose of contents/container to..… |
Computed Descriptors for Emodin
InChIKey | RHMXXJGYXNZAPX-UHFFFAOYSA-N |
Emodin manufacturer
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