Danoprevir
- CAS NO.：850876-88-9
- Empirical Formula: C35H46FN5O9S
- Molecular Weight: 731.83
- MDL number: MFCD16038038
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-15 19:19:13
What is Danoprevir?
Description
Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).
The Uses of Danoprevir
Danoprevir is a selective and potent inhibitor of Hepatitis C virus.
What are the applications of Application
Danoprevir is an inhibitor of the NS3/4A protease of hepatitis C virus (HCV)
Properties of Danoprevir
| Melting point: | >165°C (dec.) |
| Density | 1.41 |
| storage temp. | -20°C Freezer |
| solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.43±0.60(Predicted) |
| color | White to Pale Beige |
Safety information for Danoprevir
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Danoprevir
| InChIKey | ZVTDLPBHTSMEJZ-AIYSODCISA-N |
| SMILES | C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33| |
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