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HomeProduct name listResibufogenin

Resibufogenin

Synonym(s):14,15-β-epoxy-3-β-hydroxy-5-β-bufa-20,22-dienolide;Bufogenin;RBG;Recibufogenin;Respigon

  • CAS NO.:465-39-4
  • Empirical Formula: C24H32O4
  • Molecular Weight: 384.51
  • MDL number: MFCD00210361
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
Resibufogenin Structural

What is Resibufogenin?

Description

As one of the active components of Bufonis bufa, Resibufogenin is speculated that Etobufaxin can inhibit the proliferation of tumor cells by inducing apoptosis of osteosarcoma cells.

The Uses of Resibufogenin

Resibufogenin is used for content determination/identification/pharmacological experiments, etc.

What are the applications of Application

Resibufogenin is a specific inhibitor of Na+/K+-ATPase

Definition

ChEBI: Bufogenin is a steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a steroid lactone and an epoxy steroid. It is functionally related to a bufanolide.

Biological Activity

Resibufogenin (Bufogenin, Recibufogenin) is the anticancer component of huachansu cinobufogenin, which triggers necrosis by up-regulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating Ser358 of mixed lineage kinase domain-like protein. It exerts cytotoxic effects by inducing the accumulation of reactive oxygen species (ROS). Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Also it increases Bax/Bcl-2 expression and inhibits protein expression of cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin.

Pharmacokinetics

The main pharmacological action of acetobufaxin is anti-tumor. The cinobufavidin injection was separated by modern chromatographic techniques, and the exobufaxin compounds were obtained. The main monomers of exobufaxin were analyzed and identified by HPLC-DAD-FT-ICR-MS. The anti-tumor activity of exobufaxin was screened in vitro, and the pancreatic cancer tumor-bearing nude mouse model was established in vivo to evaluate the efficacy of exobufaxin.

Properties of Resibufogenin

Melting point: 113-140°/155-168°
Boiling point: 431.17°C (rough estimate)
alpha  D22 -7.1° (c = 1.259 in chloroform); D16 -5.4° (c = 2.030 in chloroform)
Density  1.0474 (rough estimate)
refractive index  1.4860 (estimate)
storage temp.  under inert gas (nitrogen or Argon) at 2-8°C
solubility  DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 20 mg/mL; Ethanol: 5 mg/mL
pka 15.14±0.70(Predicted)
form  White to off-white solid.
color  White to off-white
Stability: Moisture Sensitive

Safety information for Resibufogenin

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
Precautionary Statement Codes P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P262:Do not get in eyes, on skin, or on clothing.
P280:Wear protective gloves/protective clothing/eye protection/face protection.

Computed Descriptors for Resibufogenin

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