Resibufogenin
Synonym(s):14,15-β-epoxy-3-β-hydroxy-5-β-bufa-20,22-dienolide;Bufogenin;RBG;Recibufogenin;Respigon
- CAS NO.:465-39-4
- Empirical Formula: C24H32O4
- Molecular Weight: 384.51
- MDL number: MFCD00210361
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-12 08:58:12
What is Resibufogenin?
Description
As one of the active components of Bufonis bufa, Resibufogenin is speculated that Etobufaxin can inhibit the proliferation of tumor cells by inducing apoptosis of osteosarcoma cells.
The Uses of Resibufogenin
Resibufogenin is used for content determination/identification/pharmacological experiments, etc.
What are the applications of Application
Resibufogenin is a specific inhibitor of Na+/K+-ATPase
Definition
ChEBI: Bufogenin is a steroid lactone of Chan su (toad venom), a Chinese medicine obtained from the skin venom gland of toads. A specific Na/K-ATPase protein inhibitor, it is used as a cardiotonic and central nervous system (CNS) respiratory agent, an analgesic and anesthetic, and as a remedy for ulcers. It has a role as an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a steroid lactone and an epoxy steroid. It is functionally related to a bufanolide.
Biological Activity
Resibufogenin (Bufogenin, Recibufogenin) is the anticancer component of huachansu cinobufogenin, which triggers necrosis by up-regulating receptor-interacting protein kinase 3 (RIP3) and phosphorylating Ser358 of mixed lineage kinase domain-like protein. It exerts cytotoxic effects by inducing the accumulation of reactive oxygen species (ROS). Resibufogenin induces apoptosis and caspase-3 and caspase-8 activity. Also it increases Bax/Bcl-2 expression and inhibits protein expression of cyclin D1, cyclin E, PI3K, p-AKT, p-GSK3β and β-catenin.
Pharmacokinetics
The main pharmacological action of acetobufaxin is anti-tumor. The cinobufavidin injection was separated by modern chromatographic techniques, and the exobufaxin compounds were obtained. The main monomers of exobufaxin were analyzed and identified by HPLC-DAD-FT-ICR-MS. The anti-tumor activity of exobufaxin was screened in vitro, and the pancreatic cancer tumor-bearing nude mouse model was established in vivo to evaluate the efficacy of exobufaxin.
Properties of Resibufogenin
Melting point: | 113-140°/155-168° |
Boiling point: | 431.17°C (rough estimate) |
alpha | D22 -7.1° (c = 1.259 in chloroform); D16 -5.4° (c = 2.030 in chloroform) |
Density | 1.0474 (rough estimate) |
refractive index | 1.4860 (estimate) |
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMF: 25 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 20 mg/mL; Ethanol: 5 mg/mL |
pka | 15.14±0.70(Predicted) |
form | White to off-white solid. |
color | White to off-white |
Stability: | Moisture Sensitive |
Safety information for Resibufogenin
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
Precautionary Statement Codes |
P260:Do not breathe dust/fume/gas/mist/vapours/spray. P262:Do not get in eyes, on skin, or on clothing. P280:Wear protective gloves/protective clothing/eye protection/face protection. |
Computed Descriptors for Resibufogenin
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