R788(Fostamatinib disodium)
- CAS NO.:1025687-58-4
- Empirical Formula: C23H27FN6NaO9P
- Molecular Weight: 604.46
- MDL number: MFCD15146370
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-17 16:00:36
![R788(Fostamatinib disodium) Structural](https://img.chemicalbook.in/CAS/20150408/GIF/1025687-58-4.gif)
What is R788(Fostamatinib disodium)?
The Uses of R788(Fostamatinib disodium)
R 788 Sodium Salt is the sodium salt of R 788 which is a selective spleen tyrosine kinase (Syk) inhibitor. It may be used in the treatment of autoimmune diseases such as type 1 diabetes and has been tested in the treatment of rheumatoid athritis, leukemia and lymphoma.
What are the applications of Application
R935788 (Fostamatinib disodium, R788) is an inhibitor to spleenic kinase-mediated IgG Fc receptor signaling
Biological Activity
r788, which is the prodrug of r406, is a potnet and selective syk inhibitor. the spleen tyrosine kinase (syk) plays a key role in the signaling of activating fc receptors and the b-cell receptor (bcr).
in vitro
r406 was found to induce the apoptosis of the majority of examined dlbcl cell lines and could specifically inhibit both tonic- and ligand-induced bcr signaling (autophosphorylation of syk525/526 and sykdependent phosphorylation of the b-cell linker protein [blnk]) [1].
in vivo
r788 effectively inhibits bcr signaling, demonstrating reduced proliferation and survival of the malignant b cells and significantly prolonged survival of the treated eμ-tcl1 transgenic mouse. moreover, the effect of r788 was found to be selective for the malignant clones, since no disturbance in the production of normal b lymphocytes was observed [2].
References
[1] chen l, monti s, juszczynski p, daley j, chen w, witzig te, habermann tm, kutok jl, shipp ma. syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large b-cell lymphoma. blood. 2008 feb 15;111(4):2230-7.
[2] suljagic m, longo pg, bennardo s, perlas e, leone g, laurenti l, efremov dg. the syk inhibitor fostamatinib disodium (r788) inhibits tumor growth in the eμ- tcl1 transgenic mouse model of cll by blocking antigen-dependent b-cell receptor signaling. blood. 2010 dec 2;116(23):4894-905.
[3] bajpai m. fostamatinib, a syk inhibitor prodrug for the treatment of inflammatory diseases. idrugs. 2009 mar;12(3):174-85.
Properties of R788(Fostamatinib disodium)
Melting point: | >191°C (dec.) |
storage temp. | Store at -20°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | Off-White |
Stability: | Hygroscopic |
Safety information for R788(Fostamatinib disodium)
Computed Descriptors for R788(Fostamatinib disodium)
New Products
1-Amino-1-cyclohexanecarboxylic acid 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione 6-Bromo-3-iodo-1-methyl-1H-indazole 7-Bromo-1H-indazole ELECTROLYTIC IRON POWDER 1-Aminocyclobutanecarboxylic acid 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Decanonitrile N,N'-diallyl-1,3-diaminopropanedihydrochloride Methyl 5-bromo-2-chloro-3-nitrobenzoate 4-bromo-3,5-dimethylbenzenesulfonyl chloride N-(5-Amino-2-methylphenyl)acetamide methyl 6-chloro-2-(chloromethyl)nicotinate 2-methoxy-4-methyl-5-nitro pyridine 2-iodo-5-bromo pyridine 2-amino-4-methyl-5-nitro pyridine 4-cyano benzaldehyde 2-hydroxy-5-bromo pyridine 5-Fluoro-2-Oxindole 2,3-dibromopropan-1-ol 5-(tert-butyl) 1-methyl ((benzyloxy)carbonyl)-L-glutamate methyl L-alaninate hydrochloride diethyl L-glutamate hydrochlorideRelated products of tetrahydrofuran
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