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HomeProduct name listR-(-)-Apomorphine

R-(-)-Apomorphine

Synonym(s):R-(−)-Apomorphine hydrochloride hemihydrate

  • CAS NO.:41372-20-7
  • Empirical Formula: C17H20ClNO3
  • Molecular Weight: 321.8
  • MDL number: MFCD27966809
  • EINECS: 627-402-4
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-02 08:55:06
R-(-)-Apomorphine Structural

What is R-(-)-Apomorphine?

Description

Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5

Chemical properties

Off-White Solid

The Uses of R-(-)-Apomorphine

emetic, antiparkinsonian, erextile dysfunction therapy

The Uses of R-(-)-Apomorphine

Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.

The Uses of R-(-)-Apomorphine

R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo.

What are the applications of Application

R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist

brand name

Apokyn (Vernalis).

Purification Methods

Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC.

References

1) Merck Index 14:746 2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791 3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612 4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279 5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsonism. Related. Disord., 33 Suppl. 1:S13

Properties of R-(-)-Apomorphine

Melting point: 285-287 °C(lit.)
alpha  -48 º (c=1, H2O)
storage temp.  Refrigerator
solubility  H2O: ~10 mg/mL, clear, yellow-green
form  calcined
form  Solid
color  white to gray
PH pH(10g/l, 25℃) : 4.0~5.0
Merck  13,751
Stability: Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week.
CAS DataBase Reference 41372-20-7(CAS DataBase Reference)

Safety information for R-(-)-Apomorphine

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral

Computed Descriptors for R-(-)-Apomorphine

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