(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

Synonym(s):α,α-Diphenyl-D-prolinolmethylboronic acid cyclamide ester;(R)-1-Methyl,3,3-diphenyl-tetrahydro-pyrrolo(1,2-c)(1,3,2)oxazaborole;(R)-Tetrahydro-1-methyl-3,3-diphenyl-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole

CAS NO.：112022-83-0
Empirical Formula: C18H20BNO
Molecular Weight: 277.17
MDL number: MFCD00078440
EINECS: 000-000-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-12-02 14:14:00

(R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole Structural

What is (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole?

Chemical properties

white to light yellow crystal powde

The Uses of (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

suzuki reaction

The Uses of (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

(R)-2-Methyl-CBS-oxazaborolidine is used in the asymmetric reduction of prochiral ketones. Other applications include the enantioselective synthesis of α-hydroxy acids, α-amino acids, C2 symmetrical ferrocenyl diols, and propargyl alcohols. It is also used in a desymmetrizing reduction leading to (S)-4-hydroxycyclohexenone. It is useful in the production of stereospecific motifs such as α-hydroxy acids, α-amino acids, symmetrical ferrocenyl diols and propargyl alcohols.

The Uses of (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

CBS Catalysts for Asymmetric Reduction and Asymmetric Synthesis

What are the applications of Application

(R)-(+)-2-Methyl-CBS-oxazaborolidine is a chemical employed in the asymmetric reduction of prochiral ketones

Properties of (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

Melting point:	85-95 °C(lit.)
Boiling point:	111 °C
Density	0.95 g/mL at 25 °C
refractive index	68 ° (C=1, MeOH)
Flash point:	40 °F
storage temp.	room temp
solubility	soluble in Chloroform, Methanol
pka	1.02±0.40(Predicted)
form	Liquid
color	Colorless to amber
optical activity	[α]22/D +76.8°, c = 1 in toluene
Water Solubility	Not miscible or difficult to mix in water.
Sensitive	Air & Moisture Sensitive
BRN	9059874
Exposure limits	ACGIH: TWA 20 ppm OSHA: Ceiling 300 ppm; TWA 200 ppm NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
CAS DataBase Reference	112022-83-0(CAS DataBase Reference)

Safety information for (R)-3,3-Diphenyl-1-methylpyrrolidino[1,2-c]-1,3,2-oxazaborole

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H318:Serious eye damage/eye irritation
Precautionary Statement Codes	P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P501:Dispose of contents/container to..…