(R)-2-Flurbiprofen
Synonym(s):(R)-2-Flurbiprofen;Tarenflurbil
- CAS NO.:51543-40-9
- Empirical Formula: C15H13FO2
- Molecular Weight: 244.26
- MDL number: MFCD00869714
- EINECS: 257-264-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-01-27 09:38:02
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What is (R)-2-Flurbiprofen?
Description
(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen that has diverse biological activities. It inhibits γ-secretase activity in vitro and, in vivo, it reduces formation of amyloid-β peptide 1-42 (Aβ42) and improves axonal transport in young Aβ-plaque free mice but not old mice with existing Aβ plaques in the Tg2576 transgenic model of Alzheimer''s disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-κB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.
The Uses of (R)-2-Flurbiprofen
(R)-2-Flurbiprofen is the R-isomer of Flurbiprofen (F598700), an anti-inflammatory used as an analgesic.
What are the applications of Application
(R)-Flurbiprofen is an inhibitor of γ-secretase and Cox
Definition
ChEBI: (R)-flurbiprofen is a flurbiprofen. It is an enantiomer of a (S)-flurbiprofen.
Biochem/physiol Actions
gamma secretase inhibitor; amyloid Abeta 42 lowering agent
Properties of (R)-2-Flurbiprofen
Melting point: | 110-113 °C(lit.) |
Boiling point: | 376.2±30.0 °C(Predicted) |
Density | 1.199±0.06 g/cm3(Predicted) |
storage temp. | Store at RT |
solubility | DMF: 25 mg/ml; DMSO: 10 mg/ml; Ethanol: 25 mg/ml; PBS (pH 7.2): .9 mg/ml |
form | Crystalline Powder |
pka | 4.14±0.10(Predicted) |
color | White to off-white |
Safety information for (R)-2-Flurbiprofen
Signal word | Danger |
Pictogram(s) |
![]() Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H301:Acute toxicity,oral |
Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for (R)-2-Flurbiprofen
New Products
1-Amino-1-cyclohexanecarboxylic acid 6-Bromo-3-iodo-1-methyl-1H-indazole 3-(2,4-Dimethoxybenzyl)dihydropyrimidine-2,4(1H,3H)-dione S-Methylisothiosemicarbazide hydroiodide ELECTROLYTIC IRON POWDER 1-Aminocyclobutanecarboxylic acid 1-(2-Ethoxyethyl)-2-(piperidin-4-yl)-1H-benzo[d]imidazole hydrochloride tert-butyl 4-(1H-benzo[d]iMidazol-2-yl)piperidine-1-carboxylate Decanonitrile N,N'-diallyl-1,3-diaminopropanedihydrochloride N-(3-Nitrophenyl)cyclopropanecarboxamide (2-amino-2-phenylethyl)(methyl)amine Methyl-2-acetamidobenzoate methyl 6-chloro-2-(chloromethyl)nicotinate 2-methoxy-4-methyl-5-nitro pyridine 2-iodo-5-bromo pyridine 2-amino-4-methyl-5-nitro pyridine 4-cyano benzaldehyde 2-hydroxy-5-bromo pyridine 5-Fluoro-2-Oxindole 3,5-Dichloro-2,6-Dimethyl-1h-Pyridin-4-One (9H-fluoren-9-yl)methyl carbonochloridate 2-methyl-5-nitroaniline (S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acidRelated products of tetrahydrofuran
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