(R)-(-)-2-Aminobutane
Synonym(s):(R)-(−)-2-Aminobutane
- CAS NO.:13250-12-9
- Empirical Formula: C4H11N
- Molecular Weight: 73.14
- MDL number: MFCD00064416
- EINECS: 236-232-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is (R)-(-)-2-Aminobutane?
Chemical properties
Colorless to light yellow liqui
The Uses of (R)-(-)-2-Aminobutane
(R)-(-)-2-Aminobutane is a chiral amine plays an important role in pharmaceutical chemistry and in organic synthesis as chiral auxiliary, which is used to determine the enantiomeric excess (ee).
The Uses of (R)-(-)-2-Aminobutane
(R)-(?)-sec-Butylamine can be used:
- To prepare (R)-(?)-sec-butylbis(2-hydroxyethyl)amine, an intermediate for the synthesis of aminodiphosphine ligands.
- As a substrate to demonstrate the stereochemistry of Mitsunobu reaction in the synthesis of secondary amines.
- As a model compound in the study of singlet-triplet transitions in circular dichroism.
Purification Methods
Dry it over solid NaOH overnight and fractionate it through a short helices packed column. The L-hydrogen tartrate salt has m 139-140o (from H2O), the 1H2O has m 96o []D +18.1o (c 11, H2O), the hydrochloride has m 152o [ ] 21 -1.1o (c 13, H2O) and the benzoyl derivative crystallises from EtOH as needles with m 97o, [] 21 -34.9o (c 11, H2O). [Bruck et al. J Chem Soc 921 1956,Kjaer & Hansen Acta Chem Scand 11 898 1957.] [Beilstein 4 H 161, 4 I 372, 4 III 308, 4 IV 617.] The S -(+)-enantiomer has has same properties except for the optical rotation which has the opposite sign.
Properties of (R)-(-)-2-Aminobutane
Melting point: | -105°C |
Boiling point: | 63 °C(lit.) |
alpha | -7.5 º (c=neat 19 ºC) |
Density | 0.72 g/mL at 25 °C(lit.) |
refractive index | n |
Flash point: | -19°C |
storage temp. | Flammables area |
form | clear liquid |
pka | 10.74±0.10(Predicted) |
color | Colorless to Almost colorless |
optical activity | [α]19/D 7.5°, neat |
Water Solubility | > 10 mg/L |
Sensitive | Air Sensitive |
Merck | 14,1544 |
BRN | 1718760 |
CAS DataBase Reference | 13250-12-9(CAS DataBase Reference) |
Safety information for (R)-(-)-2-Aminobutane
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07 Environment GHS09 |
GHS Hazard Statements |
H225:Flammable liquids H314:Skin corrosion/irritation H410:Hazardous to the aquatic environment, long-term hazard |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for (R)-(-)-2-Aminobutane
New Products
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