Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listPURPUROGALLIN

PURPUROGALLIN

  • CAS NO.:569-77-7
  • Empirical Formula: C11H8O5
  • Molecular Weight: 220.18
  • MDL number: MFCD00004145
  • EINECS: 209-324-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
PURPUROGALLIN Structural

What is PURPUROGALLIN?

Description

Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties. It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 μg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 μg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC50 = 55 μM). Purpurogallin (2, 5, and 10 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes. It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC50s = 27.5, 8, 16, and 50 μM, respectively), as well as catechol O-methyltransferase (COMT; Ki = 0.074 μM), in cell-free assays.

Chemical properties

BROWN FINE CRYSTALLINE POWDER

The Uses of PURPUROGALLIN

xanthine oxidase inhibitor, antioxidant

Definition

ChEBI: A cyclic ketone that is 5H-benzocycloheptene bearing an oxo group at position 5 and hydroxy groups at positions 2, 3, 4 and 6.

Enzyme inhibitor

This aglycone (FW = 220.18 g/mol) of a number of glycosides (e.g., dryophantin) from several nutgalls. Purpurogallin is a scavenger of polymorphonuclear leukocyte-derived oxyradicals and acts as a cardioprotector. Target(s): catechol O-methyltransferase; cystathionine b-synthase; glutathione-disulfide reductase; glutathione S-transferase; HIV-1 integrase; lactoylglutathione lyase, or glyoxalase I; 3-phosphoglycerate kinase; prolyl endopeptidase; protein-tyrosine kinase; and xanthine oxidase.

Properties of PURPUROGALLIN

Melting point: 275 °C (dec.)(lit.)
Boiling point: 321.11°C (rough estimate)
Density  1.3824 (rough estimate)
refractive index  1.5140 (estimate)
storage temp.  −20°C
solubility  DMSO (Slightly), Methanol (Slightly)
pka 6.75±0.20(Predicted)
form  Solid
color  Very Dark Brown
Merck  7946
Stability: Air Sensitive

Safety information for PURPUROGALLIN

Computed Descriptors for PURPUROGALLIN

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.