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HomeProduct name listPURPUROGALLIN

PURPUROGALLIN

  • CAS NO.:569-77-7
  • Empirical Formula: C11H8O5
  • Molecular Weight: 220.18
  • MDL number: MFCD00004145
  • EINECS: 209-324-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
PURPUROGALLIN Structural

What is PURPUROGALLIN?

Description

Purpurogallin is a phenol that has been found in D. divisa and a derivative of pyrogallol that has diverse biological activities, including antimicrobial, antioxidant, and enzyme inhibitory properties. It is active against the Gram-positive bacteria S. aureus, methicillin-resistant S. aureus (MRSA), S. epidermidis, and B. subtilis (MICs = 11-110 μg/ml), the Gram-negative bacteria S. marcescens, P. vulgaris, K. pneumoniae, E. coli, S. typhi, and E. cloacae (MIC = 110 μg/ml for all), as well as P. falciparum strain FCB1 clone NC-1 (IC50 = 55 μM). Purpurogallin (2, 5, and 10 μM) scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay and reduces hydrogen peroxide- and radiation-induced production of reactive oxygen species (ROS) in HaCaT keratinocytes. It inhibits the activity of EGFR, glutathione-S-transferase (GST), prolyl endopeptidase, and glyoxalase I (IC50s = 27.5, 8, 16, and 50 μM, respectively), as well as catechol O-methyltransferase (COMT; Ki = 0.074 μM), in cell-free assays.

Chemical properties

BROWN FINE CRYSTALLINE POWDER

The Uses of PURPUROGALLIN

xanthine oxidase inhibitor, antioxidant

Definition

ChEBI: A cyclic ketone that is 5H-benzocycloheptene bearing an oxo group at position 5 and hydroxy groups at positions 2, 3, 4 and 6.

Enzyme inhibitor

This aglycone (FW = 220.18 g/mol) of a number of glycosides (e.g., dryophantin) from several nutgalls. Purpurogallin is a scavenger of polymorphonuclear leukocyte-derived oxyradicals and acts as a cardioprotector. Target(s): catechol O-methyltransferase; cystathionine b-synthase; glutathione-disulfide reductase; glutathione S-transferase; HIV-1 integrase; lactoylglutathione lyase, or glyoxalase I; 3-phosphoglycerate kinase; prolyl endopeptidase; protein-tyrosine kinase; and xanthine oxidase.

Properties of PURPUROGALLIN

Melting point: 275 °C (dec.)(lit.)
Boiling point: 321.11°C (rough estimate)
Density  1.3824 (rough estimate)
refractive index  1.5140 (estimate)
storage temp.  −20°C
solubility  DMSO (Slightly), Methanol (Slightly)
pka 6.75±0.20(Predicted)
form  Solid
color  Very Dark Brown
Merck  7946
Stability: Air Sensitive

Safety information for PURPUROGALLIN

Computed Descriptors for PURPUROGALLIN

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