Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listPyrogallol

Pyrogallol

Synonym(s):1,2,3-Trihydroxybenzene;2,3-Dihydroxyphenol;Pyrogallic acid;Pyrogallic acid, 1,2,3-Trihydroxybenzene;Pyrogallol

  • CAS NO.:87-66-1
  • Empirical Formula: C6H6O3
  • Molecular Weight: 126.11
  • MDL number: MFCD00002192
  • EINECS: 201-762-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 20:04:50
Pyrogallol Structural

What is Pyrogallol?

Description

Pyrogallol is a natural oxidant that can generate superoxide (O2-) in alkaline solutions through autoxidation to a semiquinone radical. Importantly, the semiquinone radical can react with O2- in an acidic environment to produce a quinone and H2O2. Pyrogallol autoxidation is used in superoxide dismutase activity assays. It can also be used in assays to assess antioxidant capacity. Pyrogallol is used in some biological systems as an O2- scavenger. In other biological systems, it is used as an O2- generator. Pyrogallol effectively scavenges DPPH radical and ABTS+ in vitro. Pyrogallol is a product of tannin degradation to gallic acid by ruminant microbes and has hepatotoxic and nephrotoxic effects in vivo.

Chemical properties

white crystalline solid

Chemical properties

White or nearly white needle- or leaf-shaped crystals or crystalline powder.Pyrogallol is practically odorless.

The Uses of Pyrogallol

Pyrogallol possesses importance as a spectrophotometric reagent in the determination of niobium and tantalum. The absorptions of niobium and tantalum complexes are usually measured at 340 and 335 nm, respectively. The niobium complex is formed in slightly acidic medium, and the tantalum complex in strongly acidic medium (4 N HC1). The absorption spectra are pH-dependen.

The Uses of Pyrogallol

Complexing agent; reducing agent; alkaline solution indicator for gaseous oxygen.

The Uses of Pyrogallol

Pyrogallol is used in the manufacture of various dyes; in dyeing furs, hairs, and feathers; for staining leather; in engraving;as a developer in photography; and as an analytical reagent..

What are the applications of Application

Pyrogallol is a metal-complexing benzene triol compound

Definition

ChEBI: A benzenetriol carrying hydroxy groups at positions 1, 2 and 3.

Production Methods

Pyrogallol is prepared by heating dried gallic acid at about 200°C with the loss of carbon dioxide or by the chlorination of cyclohexanol to tetrachlorocyclohexanone, followed by hydrolysis.

General Description

Odorless white to gray solid. Sinks and mixes with water.

Air & Water Reactions

Turns gray on exposure to light or air. Water soluble.

Reactivity Profile

Pyrogallol is a strong reducing agent. Reacts with alkalis, NH3, antipyrine, camphor, phenol, iron and lead salts, iodine, lime water, menthol and KMnO4.

Hazard

Toxic by ingestion and skin absorption.

Health Hazard

Inhalation of dust causes irritation of nose and throat. Ingestion may cause severe gastrointestinal irritation, convulsions, circulatory collapse, and death. Contact with eyes causes irritation. Skin contact can cause local discoloration, irritation, eczema, and death; repeated contact can cause sensitization.

Health Hazard

The toxic symptoms are similar to those of phenol. It can enter the body by absorption through skin and ingestion. The poisoning effects are nausea, vomiting, gastritis, hemolysis, methemoglobinemia, kidney and liver damage, convulsions, and congestion of lungs. High doses can cause death. Ingestion of 2–3 g of solid can be fatal to humans. The LD50 values varied widely in species. The oral LD50 value in mice is about 300 mg/kg.

Fire Hazard

Pyrogallol is probably combustible.

Contact allergens

Pyrogallol belongs to the phenols group. It is an old photograph developer and a low sensitizer in hair dyes.

Biochem/physiol Actions

Pyrogallol also referred to as 1,2,3-trihydroxybenzene inhibits the response to nitric oxide (NO) in the rat anococcygeus muscle.

Safety Profile

Human poison by ingestion and subcutaneous routes. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. 1 198 PPRSOO PYROSULFURYL CHLORIDE Readdy absorbed through the skin. Human systemic effects by ingestion: convulsions, dyspnea, gastrointestinal effects. A severe skin and eye irritant. Incompatible with alkalies, NH3, antipyrine, phenol, iron and lead salts, iodine, KMn04. When heated to decomposition it emits acrid smoke and irritating fumes. Used as a topical antibacterial agent, as an intermediate, hair dye component, and analytical reagent.

Carcinogenicity

Pyrogallol was not carcinogenic in mouse and rabbit chronic dermal studies. Mice were treated twice weekly with pyrogallol in acetone (50%) on the shaved flank for life. There was no increase in dermal or systemic tumors. A similar study in rabbits also revealed no skin tumors, although positive controls showed an increase in tumors in both mice and rabbits.
Pyrogallol was considered to be cocarcinogenic when administered dermally three times a week together with the skin carcinogen benzo[a]pyrene for 440 days; pyrogallol administered alone caused no increase in skin tumors.

Properties of Pyrogallol

Melting point: 43-47 °C(lit.)
Boiling point: 309 °C
Density  1.112 g/mL at 25 °C(lit.)
vapor density  4.4 (vs air)
vapor pressure  10 mm Hg ( 167.7 °C)
refractive index  n20/D 1.387
Flash point: >230 °F
storage temp.  Store below +30°C.
solubility  water: soluble
form  Very Fine Crystalline Powder
pka pK1:9.03(0);pK2:11.63(+1) (25°C)
color  White
PH 4-5 (50g/l, H2O, 20℃)
Water Solubility  400 g/L (25 ºC)
Sensitive  Light Sensitive
Merck  14,8000
BRN  907431
Stability: Stable, but decolourises in light. Combustible. Incompatible with strong oxidising agents, alkalies, metal oxides, ammonia, antipyrine, phenol, iodine, lime water, menthol, potassium permanganate, strong bases.
CAS DataBase Reference 87-66-1(CAS DataBase Reference)
NIST Chemistry Reference 1,2,3-Benzenetriol(87-66-1)
EPA Substance Registry System Pyrogallol (87-66-1)

Safety information for Pyrogallol

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H341:Germ cell mutagenicity
H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Pyrogallol

InChIKey WQGWDDDVZFFDIG-UHFFFAOYSA-N

Abamectin manufacturer

JSK Chemicals

1Y
Phone:+919879767970
Whatsapp: +91 9879767970
product: 87-66-1 Pyrogallol, 99% 99%
Inquiry

Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: 87-66-1 98%
Inquiry

Twinkle Chemi Lab Pvt Ltd

1Y
Phone:+91-9822390838
Whatsapp: +91-9822390838
product: Pyrogallol 99%
Inquiry

ARRAKIS INDUSTRIES LLP

1Y
Phone:+91-7499586750
Whatsapp: +91- 7499586750
product: PYROGALLOL 99%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.