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HomeProduct name listpsoralidin

psoralidin

Synonym(s):3,9-Dihydroxy-2-(3-methyl-2-butenyl)-6H-benzofuro[3,2-c][1]benzopyran-6-one;3,9-Dihydroxy-2-prenylcoumestan

psoralidin Structural

What is psoralidin?

Description

Psoralidin is a furanocoumarin isolated from the seeds of P. corylifolia, a medicinal plant found in southeastern Asia, that has been shown to induce cytotoxicity against various cancer cells. Through TNF-related apoptosis-inducing ligand-mediated events, psoralidin at 50 μM can induce the death of HeLa cancer cells. It also can induce apoptosis of androgen-dependent (LNCaP, C4-2B) and androgen-independent (DU-145, PC-3) prostate cancer cells and inhibit the growth of PC-3 xenograft tumors in nude mice.

The Uses of psoralidin

Psoralidin is an antibacterial and antioxidant reagent.

What are the applications of Application

Psoralidin is an antibacterial and antioxidant reagent

Definition

ChEBI: A member of the class of coumestans that is coumestan substituted by hydroxy groups at positions 3 and 9 and a prenyl group at position 2 respectively.

References

[1] yang h j, youn h s, seong k m, et al. psoralidin, a dual inhibitor of cox-2 and 5-lox, regulates ionizing radiation (ir)-induced pulmonary inflammation[j]. biochemical pharmacology, 2011, 82(5): 524-534.
[2] chiou w f, don m j, liao j f, et al. psoralidin inhibits lps-induced inos expression via repressing syk-mediated activation of pi3k-ikk-iκb signaling pathways[j]. european journal of pharmacology, 2011, 650(1): 102-109.
[3] bronikowska j, szliszka e, jaworska d, et al. the coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (trail)[j]. molecules, 2012, 17(6): 6449-6464.

Properties of psoralidin

Melting point: 290-292°
Boiling point: 458.8±34.0 °C(Predicted)
Density  1.383±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility  DMSO: soluble5mg/mL, clear (warmed)
form  powder
pka 8.70±0.20(Predicted)
color  white to beige

Safety information for psoralidin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral

Computed Descriptors for psoralidin

InChIKey YABIJLLNNFURIJ-UHFFFAOYSA-N

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