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HomeProduct name listProtopine

Protopine

Synonym(s):4,6,7,14-Tetrahydro-5-methylbis[1,3]benzodioxolo[4,5-c:5′,6′-g]azecin-13(5H)-one

  • CAS NO.:130-86-9
  • Empirical Formula: C20H19NO5
  • Molecular Weight: 353.37
  • MDL number: MFCD00022322
  • EINECS: 204-999-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
Protopine Structural

What is Protopine?

Chemical properties

Off-White Solid

The Uses of Protopine

Protopine is a Ca2+ channel blocker and antiplatelet agent. Immunomodulator

Definition

ChEBI: A dibenzazecine alkaloid isolated from Fumaria vaillantii.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Purification Methods

It crystallises from EtOH/CHCl3. The picrate has m ~240o(dec). [Beilstein 27 H 558, 17 I 568, 17 II 620, 17 III/IV 6881.]

Properties of Protopine

Melting point: 203-205?C
Boiling point: 486.8°C (rough estimate)
Density  1.399 (calc)
refractive index  1.5800 (estimate)
storage temp.  Inert atmosphere,2-8°C
Water Solubility  Insoluble in water
solubility  DMSO : 12.5 mg/mL (35.37 mM; Need ultrasonic)
form  powder to crystal
pka 7.86±0.20(Predicted)
color  White to Light gray to Light yellow
NIST Chemistry Reference Protopine(130-86-9)

Safety information for Protopine

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P501:Dispose of contents/container to..…

Computed Descriptors for Protopine

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