protamine sulfate
Synonym(s):Protamine sulfate;Salmine sulfate;Salmine sulfate from salmon sperm
- CAS NO.:98001-69-5
- Molecular Weight: 0
- Update Date: 2023-07-07 13:12:37
What is protamine sulfate?
The Uses of protamine sulfate
Protamine sulfate has been used in the transduction of
- lentiviruses into human embryonic 293T cells
- shRNA into mesenchymal stem cells/marrow stromal cells (MSC)
- lenti Sca1-OCT4 plasmid into human cord blood hematopoietic progenitor CD34+ cells
The Uses of protamine sulfate
Antidote (to heparin).
General Description
Protamine sulfate has an anticoagulanteffect, but if used in the proper amount, it counteractsthe action of heparin and is used as an antidote for thelatter in cases of overdosage. It is administered intravenouslyin a dose that depends on the circumstances.
Biochem/physiol Actions
Alkaline protamine binds to negatively charged heparin. Use of protamine during cardiovascular surgery sometime triggers anaphylactic reactions.
Veterinary Drugs and Treatments
Protamine is used in all species for the treatment of heparin overdosage when significant bleeding occurs. While protamine will neutralize the anti-thrombin effects of low molecular weight heparins (e.g., dalteparin or enoxaparin), it does not completely inhibit their anti-Xa activity. Laboratory animal studies however, shows it does improve microvascular bleeding associated with LMWH overdoses. Protamine has been suggested for use for Bracken Fern toxicity in ruminants (see Doses).
Properties of protamine sulfate
storage temp. | 2-8°C |
Safety information for protamine sulfate
Computed Descriptors for protamine sulfate
Related products of tetrahydrofuran
You may like
-
Protamine sulfate CASView Details
-
77-92-9 99%View Details
77-92-9 -
77-92-9 99%View Details
77-92-9 -
8000-27-9 CEDAR WOOD OIL 99%View Details
8000-27-9 -
AMMONIUM DICHROMATE 7789-09-5 99%View Details
7789-09-5 -
77-78-1 DIMETHYL SULPHATE 99%View Details
77-78-1 -
7778-80-5 POTASSIUM SULPHATE 99%View Details
7778-80-5 -
95-54-5 99%View Details
95-54-5