PROSTAGLANDIN J2

CAS NO.：60203-57-8
Empirical Formula: C20H30O4
Molecular Weight: 334.45
MDL number: MFCD00065804
EINECS: 201-185-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-07-02 08:55:09

What is PROSTAGLANDIN J2?

Description

Prostaglandin J₂ (PGJ₂) is formed from PGD₂ by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin. PGJ₂ inhibits platelet aggregation with an IC₅₀ of about 5-10 nM. PGJ₂ has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines. However, this activity has been attributed to further metabolites of PGJ₂ and not the parent compound itself.

The Uses of PROSTAGLANDIN J2

PGJ2 (Prostaglandin J2) is a Prostaglandin D2 metabolite that has shown potent anti-neoplastic and antiviral activity.

What are the applications of Application

PGJ2 (Prostaglandin J2) is a Prostaglandin D2 metabolite that has shown potent anti-neoplastic and antiviral activity

Definition

ChEBI: A member of the class of prostaglandins J that consists of prosta-5,9,13-trien-1-oic acid substituted by an oxo group at position 11 and a hydroxy group at position 15 (the 5Z,13E,15S stereoisomer).

Properties of PROSTAGLANDIN J2

Boiling point:	521.7±50.0 °C(Predicted)
Density	1.103±0.06 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMF: >100 mg/ml (from PGD2); DMSO: >50 mg/ml (from PGD2); Ethanol: >75 mg/ml (from PGD2); PBS pH 7.2: >2.7 mg/ml (from 15-deoxy-.DEL
pka	4.75±0.10(Predicted)
form	Liquid
color	Colorless to light yellow