Propiverine hydrochloride

Synonym(s):α,α-Diphenyl-α-propoxyacetic acid hydrochloride 1-methyl-4-piperidyl ester;α-Phenyl-α-propoxybenzeneacetic acid 1-methyl-4-piperidinyl ester hydrochloride;(1-Methylpiperidin-1-ium-4-yl) 2,2-diphenyl-2-propoxyacetate chloride;1-Methyl-4-piperidyl diphenylpropoxyacetate hydrochloride

CAS NO.：54556-98-8
Empirical Formula: C23H30ClNO3
Molecular Weight: 403.94
MDL number: MFCD01672343
SAFETY DATA SHEET (SDS)
Update Date: 2024-04-25 13:42:50

What is Propiverine hydrochloride?

Description

Propiverine hydrochloride is a new urological agent developed for pollakuria and aconuresis. It appears to exhibit anticholinergic properties and in animal experiments inhibited KCl induced contractions in the bladder and ileum.

Chemical properties

Off-White Solid

Originator

Apogepha (Germany)

The Uses of Propiverine hydrochloride

Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic.

What are the applications of Application

Propiverine, Hydrochloride is used for treatment of urinary incontinence

Definition

ChEBI: Propiverine hydrochloride is a diarylmethane.

brand name

Mictonorm; Mictonetten

General Description

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

Biochem/physiol Actions

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.

Clinical Use

Treatment of urinary frequency, urgency and incontinence
Neurogenic bladder instability

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.

Metabolism

Propiverine is extensively metabolised by intestinal and hepatic enzymes. Four metabolites were identified in urine; two of them are pharmacologically active and may contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine, bile and faeces.

Properties of Propiverine hydrochloride

Melting point:	224-226°C
storage temp.	2-8°C
solubility	H2O: soluble5mg/mL, clear (warmed)
form	powder
color	white to beige
CAS DataBase Reference	54556-98-8(CAS DataBase Reference)

Safety information for Propiverine hydrochloride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H318:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water.