propargyl-PEG3-Acid
- CAS NO.:1347760-82-0
- Empirical Formula: C10H16O5
- Molecular Weight: 216.23
- MDL number: MFCD22201521
- Update Date: 2024-03-26 17:16:27
What is propargyl-PEG3-Acid?
Description
Propargyl-PEG3-acid is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.
The Uses of propargyl-PEG3-Acid
Propargyl-PEG3-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG3-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.
Properties of propargyl-PEG3-Acid
storage temp. | -20°C |
solubility | Soluble in Water, DMSO, DCM, DMF |
form | clear liquid |
color | Light yellow to Brown |
Safety information for propargyl-PEG3-Acid
Computed Descriptors for propargyl-PEG3-Acid
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