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HomeProduct name listPropargyl-PEG4-thiol

Propargyl-PEG4-thiol

  • CAS NO.:1347750-80-4
  • Empirical Formula: C11H20O4S
  • Molecular Weight: 248.3391
  • MDL number: MFCD29764343
  • Update Date: 2023-04-23 13:52:06
Propargyl-PEG4-thiol Structural

What is Propargyl-PEG4-thiol?

Description

Propargyl-PEG4-thiol is a crosslinker containing a propargyl group and thiol group. The propargyl group can form triazole linkage with azide-bearing compounds or biomolecules via copper catalyzed Click Chemistry reactions. The thiol group reacts with maleimide, OPSS, vinylsulfone and transition metal surfaces including gold, silver, etc.

Biological Activity

Propargyl-PEG4-thiol is a PROTAC linker and belongs to the PEG class. It can be used to synthesize a series of PROTAC molecules. It is a non-cleavable ADC linker used in the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Properties of Propargyl-PEG4-thiol

Boiling point: 332.9±37.0 °C(Predicted)
Density  1.064±0.06 g/cm3(Predicted)
solubility  Soluble in DMSO, DCM, DMF
pka 9?+-.0.10(Predicted)

Safety information for Propargyl-PEG4-thiol

Computed Descriptors for Propargyl-PEG4-thiol

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