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HomeProduct name listPropargyl-PEG4-acid

Propargyl-PEG4-acid

Synonym(s):4,7,10,13-Tetraoxahexadec-15-ynoic acid;Propargyl-PEG4-CH2CO2H

  • CAS NO.:1415800-32-6
  • Empirical Formula: C12H20O6
  • Molecular Weight: 260.28
  • MDL number: MFCD22683284
  • Update Date: 2024-10-28 23:16:16
Propargyl-PEG4-acid Structural

What is Propargyl-PEG4-acid?

Description

Propargyl-PEG4-acid is a PEG reagent with an alkyne and a terminal carboxylic acid. The carboxylic acid reacts with primary amine groups with the help of activators (e.g. EDC, or HATU). The 4-unit PEG spacer increases hydrophilicity. The alkyne can participate in copper-catalyzed Click Chemistry.

The Uses of Propargyl-PEG4-acid

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG4-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Properties of Propargyl-PEG4-acid

Boiling point: 388.0±37.0 °C(Predicted)
Density  1.129±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in Water, DMSO, DCM, DMF
pka 4.28±0.10(Predicted)
form  Viscous Liquid
color  Colorless to light yellow

Safety information for Propargyl-PEG4-acid

Signal word Danger
Pictogram(s)
ghs
Flame
Flammables
GHS02
GHS Hazard Statements H242:Self-reactive substances and mixtures; and Organic peroxides
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P234:Keep only in original container.
P235:Keep cool.
P240:Ground/bond container and receiving equipment.
P370+P378:In case of fire: Use … for extinction.
P403:Store in a well-ventilated place.

Computed Descriptors for Propargyl-PEG4-acid

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