Acetylene-PEG5-acid

Synonym(s):Acetylene-PEG5-acid

CAS NO.：1245823-51-1
Empirical Formula: C14H24O7
Molecular Weight: 304.34
MDL number: MFCD22201536
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is Acetylene-PEG5-acid?

Description

Propargyl-PEG5-acid has a propargyl group at one end and an acid group at the other end. The acid can react with primary amines to form a stable amide bond, activation will be needed. The PEG units enhances solubility of the molecule in aqueous environment. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.

The Uses of Acetylene-PEG5-acid

Propargyl-peg5 Acid is used as a reactant in the preparation of site-specific antibody-pyrrolobenzodiazepine conjugates.

The Uses of Acetylene-PEG5-acid

Alkyne-PEG5-acid may be used in the synthesis of peptide nucleic acid (PNA) oligomers that can conjugate with vitamin B₁₂ via Cu-catalyzed 1,3-dipolar cycloaddition in order to study if vitamin B₁₂ to transport PNA oligonucleotides into bacterial cells.

Properties of Acetylene-PEG5-acid

Boiling point:	426.3±45.0 °C(Predicted)
Density	1.127±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in Water, DMSO, DCM, DMF
pka	4.28±0.10(Predicted)
form	Liquid
color	Light yellow to yellow

Safety information for Acetylene-PEG5-acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.