Acetylene-PEG5-acid
Synonym(s):Acetylene-PEG5-acid
- CAS NO.：1245823-51-1
- Empirical Formula: C14H24O7
- Molecular Weight: 304.34
- MDL number: MFCD22201536
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is Acetylene-PEG5-acid?
Description
Propargyl-PEG5-acid has a propargyl group at one end and an acid group at the other end. The acid can react with primary amines to form a stable amide bond, activation will be needed. The PEG units enhances solubility of the molecule in aqueous environment. The propargyl group can be linked to azide-containing biomolecules via Click Chemistry.
The Uses of Acetylene-PEG5-acid
Alkyne-PEG5-acid may be used in the synthesis of peptide nucleic acid (PNA) oligomers that can conjugate with vitamin B12 via Cu-catalyzed 1,3-dipolar cycloaddition in order to study if vitamin B12 to transport PNA oligonucleotides into bacterial cells.
The Uses of Acetylene-PEG5-acid
Propargyl-peg5 Acid is used as a reactant in the preparation of site-specific antibody-pyrrolobenzodiazepine conjugates.
Properties of Acetylene-PEG5-acid
| Boiling point: | 426.3±45.0 °C(Predicted) |
| Density | 1.127±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in Water, DMSO, DCM, DMF |
| pka | 4.28±0.10(Predicted) |
| form | Liquid |
| color | Light yellow to yellow |
Safety information for Acetylene-PEG5-acid
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H319:Serious eye damage/eye irritation |
| Precautionary Statement Codes |
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Acetylene-PEG5-acid
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