PROGUANIL HYDROCHLORIDE
- CAS NO.：537-21-3
- Empirical Formula: C11H15Cl2N5
- Molecular Weight: 288.18
- MDL number: MFCD01732193
- EINECS: 208-660-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:43:59
What is PROGUANIL HYDROCHLORIDE?
The Uses of PROGUANIL HYDROCHLORIDE
PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
Definition
ChEBI: Chlorproguanil is a dichlorobenzene.
Clinical Use
Malaria chemoprophylaxis
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine.
Metabolism
Proguanil is metabolised in the liver to the active metabolite, cycloguanil, and to p-chlorophenylbiguanide which is inactive, mainly by cytochrome P450, CYP 2C19 and slightly by CYP 3A4. Unlike proguanil and p-chlorophenylbiguanide, cycloguanil is not concentrated in erythrocytes so concentrations of cycloguanil in plasma and whole blood are similar. About 40-60% of a dose of proguanil is excreted in the urine, 60% of this as the unchanged drug, 30% as cycloguanil, and 8% as p-chlorophenylbiguanide. About 10% of a dose is excreted in the faeces.
Properties of PROGUANIL HYDROCHLORIDE
| Melting point: | 120-121 °C |
| Boiling point: | 350.7±52.0 °C(Predicted) |
| Density | 1.40±0.1 g/cm3(Predicted) |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 10.77±0.10(Predicted) |
| color | White to Off-White |
| Stability: | Hygroscopic |
Safety information for PROGUANIL HYDROCHLORIDE
Computed Descriptors for PROGUANIL HYDROCHLORIDE
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