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HomeProduct name listProfenofos

Profenofos

  • CAS NO.:41198-08-7
  • Empirical Formula: C11H15BrClO3PS
  • Molecular Weight: 373.63
  • MDL number: MFCD00078736
  • EINECS: 255-255-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-07-17 18:13:28
Profenofos Structural

What is Profenofos?

Description

Profenofos is a pale yellow liquid, bp 100 ?C/1.80 Pa, vp 0.124 mPa (25 ?C). Solubility in water is 28 mg/L (25 ?C). It is miscible with most organic solvents. Log Kow = 4.44. It is relatively stable in neutral and mild acid media but hydrolyzed in alkaline media; DT50 values (20 ?C) at pH 5, 7, and 9 are 93 d, 14.6 d, and 5.7 h, respectively.

Chemical properties

Profenofos is a pale yellow liquid. Profenofos is relatively stable under neutral and slightly acidic conditions and unstable under alkaline conditions.Profenofos has a garlic-like odor.
Profenofos has limited solubility in water (28 mg/L at 25°C) but is completely soluble in organic solvents (ethanol, acetone, toluene, n-octanol and n-hexane) at 25°C.

The Uses of Profenofos

Profenofos is used to control insects (particularly caterpillars and Lepidoptera eggs) and mites on cotton, maize, sugar beet, soyabean, potatoes, vegetables, tobacco and a number of other crops

The Uses of Profenofos

A broad-spectrum organophosphorous pesticide that is used widely in cotton fields for insect control.

The Uses of Profenofos

Insecticide; acaricide.

What are the applications of Application

Profenofos is a useful chemical to study pesticide interactions with cell lines

Definition

ChEBI: Profenofos is an organic thiophosphate, an organophosphate insecticide, an organochlorine insecticide and a member of monochlorobenzenes. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor, an acaricide and an agrochemical. It is functionally related to a 4-bromo-2-chlorophenol.

General Description

Pale yellow liquid with garlic-like odor. Corrosive. Used as an insecticide.

Air & Water Reactions

Hydrolyzed under alkaline conditions.

Reactivity Profile

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Agricultural Uses

Profenofos: Profenofos is A U.S. EPA restricted Use Pesticide (RUP) used solely on cotton to control a number of pests including tobacco budworm, cotton aphid and bollworm, armyworm, fleahopper and whiteflies. It is not registered for residential use. Not approved for use in EU countries. Registered for use in the U.S.

Trade name

CGA-15324®; CURACRON®; POLYCRON®; SELECRON®

Carcinogenicity

In a 2 year carcinogenicity study mice were given diets containing 0, 1, 30, or 100 ppm profenofos (equivalent to 0, 0.15, 4.5, or 15 mg/kg/day) for 85 weeks (males) or 97 weeks (females) . No treatment related clinical signs were observed. No treatment-related gross or microscopic lesions, tumors, or biologically significant differences in body weight or food consumption were observed between controls and profenofos-treated animals. Plasma and erythrocyte cholinesterase inhibition occurred at dose levels of 4.5 and 15 mg/kg/day. In another carcinogenicity study, rats were fed diets containing 0, 0.3, 10, or 100 ppm profenofos (equivalent to 0, 0.015, 0.5, or 5 mg/kg/day) for 2 years, and there was no increase in tumor incidence in any treated group compared to the control group .

Environmental Fate

Plant. Dislodgable residues of profenofos on cotton leaf 0, 24, 48, 72 and 96 hours after application (1.1 kg/ha) were 3.5, 1.1, 0.74, 0.51 and 0.35 μg/m2, respectively (Buck et al., 1980)
Photolytic. When profenofos in an aqueous buffer solution (pH 7.0) was exposed to filtered UV light (λ >290 nm) for 24 hours at 25 and 50°C, 29 and 61% respectively decomposed to 4-bromo-2-chlorophenol and 4-bromo-2-chlorophenyl ethyl hydrogen ph
Chemical/Physical. Emits toxic fumes of bromine, chlorine phosphorus and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

Metabolic pathway

The metabolic transformations of profenofos in plants and animals are similar and occur via hydrolysis to 4-bromo-2-chlorophenol which is then conjugated.

Metabolism

Profenofos orally administered to rats is rapidly excreted, mainly in the urine. The principal degradation route is hydrolysis to 4-bromo-2-chlorophenol followed by conjugation. DT50 in soil is about 1 week.

Degradation

Profenofos is stable under neutral and slightly acid conditions but it is hydrolysed in alkaline solution. The DT50 values at pH 5, 7 and 9 (20°C) were 93 days, 14.6 days and 5.7 hours, respectively (PM).

Toxicity evaluation

The acute oral LD50 for rats is 358 mg/kg. Inhalation LC50 (4 h) for rats is about 3 mg/L air. NOEL (2 yr) for rats is 0.3 mg/kg diet (0.015 mg/kg/d). ADI is 0.01 mg/kg b.w.

Properties of Profenofos

Melting point: <25 °C
Boiling point: 110°C (0.001 torr)
Density  d20 1.455
vapor pressure  1.24×10-4 Pa (25 °C)
refractive index  n20D 1.5466
Flash point: 124℃
storage temp.  APPROX 4°C
solubility  DMSO: 50 mg/mL (133.82 mM)
form  Oily Liquid
Water Solubility  28 mg l-1 (25 °C)
Specific Gravity 1.455 (20℃)
color  Colorless to light yellow
Merck  13,7860
BRN  2150258
CAS DataBase Reference 41198-08-7(CAS DataBase Reference)
NIST Chemistry Reference Phosphorothioic acid, o-(4-bromo-2-chlorophenyl) o-ethyl s-propyl ester(41198-08-7)
EPA Substance Registry System Profenofos (41198-08-7)

Safety information for Profenofos

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Environment
GHS09
GHS Hazard Statements H317:Sensitisation, Skin
H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P273:Avoid release to the environment.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

Computed Descriptors for Profenofos

Abamectin manufacturer

Gharda Chemicals Ltd

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Phone:+91-9820134485
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Gujarat Chemicals GUJCHEM

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Shreeji Pesticides

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Phone:+91-2667264701
product: Profenofos 98%
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NACL Industries Ltd

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Phone:+91-4024405100
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Spectrum Ethers Ltd

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Phone:+919312915212
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ENTOMIC CHEMICALS

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Phone:+91-9425149263
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SD Agro Chemicals

1Y
Phone:+91-9871331171
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Unique Farm Aid Pvt Ltd

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Phone:+91-9873006591
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Meghmani Organics Ltd

1Y
Phone:+91-9909030545
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