Azamethiphos

CAS NO.：35575-96-3
Empirical Formula: C9H10ClN2O5PS
Molecular Weight: 324.68
MDL number: MFCD00867611
EINECS: 252-626-0
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 23:02:33

What is Azamethiphos?

Chemical properties

white to light yellow crystal powde

The Uses of Azamethiphos

Azamethiphos is used to control flies and other insect pests in animal houses and also public hygiene and health pests such as mosquitoes and cockroaches. It has recently been used to control sea lice in salmon.

The Uses of Azamethiphos

Synergistic insecticidal and acaricidal organophosphorus compound

Definition

ChEBI: Azamethiphos is an organic thiophosphate, an organothiophosphate insecticide, an organochlorine insecticide and an organochlorine acaricide. It has a role as an EC 3.1.1.7 (acetylcholinesterase) inhibitor and an agrochemical. It is functionally related to an oxazolo[4,5-b]pyridin-2(3H)-one.

Safety Profile

Moderately toxic by ingestion andskin contact. When heated to decomposition it emits toxicvapors of NOx, SOx, POx, and Cl^- .

Metabolic pathway

Azamethiphos is metabolised in mammals via hydrolysis, followed by opening of the oxazolinone ring and conjugation of the resultant aminopyridinol as the glucuronide and sulfate ester.

Metabolism

Azamethiphos is metabolized via the cleavage of phosphorothiolate C?S bond, followed by N-demethylation and opening of the oxazolinone ring and conjugation of the resultant aminochloropyridinol as the glucuronide and sulfate ester.

Degradation

Azamethiphos is unstable in alkalis and acids. The DT₅₀ values at pH 5,7 and 9 were 800,260 and 4.3 hours, respectively (PM).

Toxicity evaluation

Acute oral LD₅₀ for rats is 1180 mg/kg. Inhalation LC50 (4 h) for rats is >560 mg/m3 air. ADI is 0.025 mg/kg.

Properties of Azamethiphos

Melting point:	88-93°C
Boiling point:	428.8±55.0 °C(Predicted)
Density	1.566±0.06 g/cm3(Predicted)
vapor pressure	4.9 x 10^-6 Pa (20 °C)
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	0.94±0.20(Predicted)
form	Solid
Water Solubility	1100 mg l^-1 (20 °C)
color	White to off-white
CAS DataBase Reference	35575-96-3(CAS DataBase Reference)
NIST Chemistry Reference	Phosphorothioic acid, s-[(6-chloro-2-oxooxazolo[4,5-b]pyridin-3(2h)-yl)methyl] o,o-dimethyl ester(35575-96-3)
EPA Substance Registry System	Azamethiphos (35575-96-3)

Safety information for Azamethiphos

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Environment GHS09
GHS Hazard Statements	H302:Acute toxicity,oral H317:Sensitisation, Skin H331:Acute toxicity,inhalation H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water.