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HomeProduct name listPROCYCLIDINE HYDROCHLORIDE

PROCYCLIDINE HYDROCHLORIDE

Synonym(s):α-Cyclohexyl-α-phenyl-1-pyrrolidinepropanol

  • CAS NO.:1508-76-5
  • Empirical Formula: C19H30ClNO
  • Molecular Weight: 323.9
  • MDL number: MFCD00079236
  • EINECS: 216-141-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-06-08 09:03:02
PROCYCLIDINE HYDROCHLORIDE Structural

What is PROCYCLIDINE HYDROCHLORIDE?

The Uses of PROCYCLIDINE HYDROCHLORIDE

An anticholinergic drug used in the treatment parkinson’s disease. It is also used to treat patients suffering from drug-induced parkinsonism, akathisia and acute dystonia.

brand name

Kemadrin (Monarch).

General Description

Procyclidine hydrochloride,α-cyclohexyl-α-phenyl-1-pyrrolidinepropanolhydrochloride (Kemadrin), was introduced in 1956. Althoughit is an effective peripheral anticholinergic and, indeed, hasbeen used for peripheral effects similar to its methochloride(i.e., tricyclamol chloride), its clinical usefulness lies inits ability to relieve voluntary muscle spasticity by its centralaction. Therefore, it has been used with success in thetreatment of Parkinson syndrome. It is said to be as effectiveas trihexyphenidyl and is used to reduce muscle rigidityin postencephalitic, arteriosclerotic, and idiopathic types ofthe disease. Its effect on tremor is not predictable and probablyshould be supplemented by combination with othersimilar drugs.
The toxicity of the drug is low, but when the dosageof the drug is high, side effects are noticeable. At therapeuticdosage levels, dry mouth is the most common sideeffect. The same care should be exercised with this drugas with all other anticholinergics when it is administeredto patients with glaucoma, tachycardia, or prostatichypertrophy.

Biochem/physiol Actions

Procyclidine is a synthetic anti-cholinergic agent and atropine-like antispasmodic. It exhibits therapeutic effects against Parkinson′s disease and schizophrenia. Procyclidine acts as a muscarinic receptor antagonist. It also affects N-methyl-D-aspartate (NMDA) glutamine and nicotinic acetylcholine receptors to a lower extent.

Clinical Use


Control of extrapyramidal symptoms
Acute dystonias

Metabolism

When given orally about one fifth of the dose is known to be metabolised in the liver, principally by cytochrome P450 and then conjugated with glucuronic acid. Metabolites have been found in the urine.

Properties of PROCYCLIDINE HYDROCHLORIDE

Melting point: 159-164 °C
storage temp.  2-8°C
solubility  Chloroform (Slightly), Methanol (Slightly), Water (Slightly)
form  Solid
color  White to Off-White

Safety information for PROCYCLIDINE HYDROCHLORIDE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.
P403:Store in a well-ventilated place.

Computed Descriptors for PROCYCLIDINE HYDROCHLORIDE

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