procyclidine
- CAS NO.:77-37-2
- Empirical Formula: C19H29NO
- Molecular Weight: 287.44
- MDL number: MFCD00057231
- EINECS: 201-023-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is procyclidine?
Toxicity
LD50=60 mg/kg (IV in mice)
The Uses of procyclidine
Antiparkinsonian; relaxant (skeletal muscle).
Background
A muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in parkinsonism.
Indications
For the treatment of all forms of Parkinson's Disease, as well as control of extrapyramidal reactions induced by antipsychotic agents.
Definition
ChEBI: A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.
brand name
Kemadrin (Monarch).
Pharmacokinetics
Procyclidine has an atropine-like action on parasympathetic-innervated peripheral structures including smooth muscle. It's antispasmodic effects are thought to be related to the blockage of central cholinergic receptors M1, M2 and M4. It is used to treat symptomatic Parkinsonism and extrapyramidal dysfunction caused by antipsychotic agents.
Synthesis
Procyclidine, 1-cyclohexyl-1-phenyl-3-pirrolidinopropan-1-ol (10.2.3), is synthesized in the exact same manner, except beginning with 2-(1-pyrrolidino) propiophenone [28–32].
Metabolism
Not Available
Properties of procyclidine
Melting point: | 85.5-86.5° |
Boiling point: | 429.73°C (rough estimate) |
Density | 0.9954 (rough estimate) |
refractive index | 1.5180 (estimate) |
pka | 14.21±0.29(Predicted) |
Water Solubility | 1.055mg/L(22.5 ºC) |
Safety information for procyclidine
Computed Descriptors for procyclidine
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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