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HomeProduct name listProadifen

Proadifen

  • CAS NO.:302-33-0
  • Empirical Formula: C23H31NO2
  • Molecular Weight: 353.5
  • MDL number: MFCD00868132
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2023-05-04 17:34:37
Proadifen Structural

What is Proadifen?

The Uses of Proadifen

Synergist (non-specific).

Definition

ChEBI: 2,2-diphenylpentanoic acid 2-(diethylamino)ethyl ester is a diarylmethane.

Enzyme inhibitor

This nonselective P450 inhibitor (FWfree-base = 353.50 g/mol; CAS 302-33-0; 62-68-0 for the HCl salt), also known as SKF-525A, b-diethylaminoethyl 2,2-diphenylpropylacetate, and N,N-diethylaminoethyl 2,2- diphenylvalerate, blocks glibenclamide-sensitive K+ channels, including ATP-sensitive inward rectifier potassium channel 8 (KIR6.1). As a nonselective inhibitor of cytochrome P450 systems, proadifen also inhibits drug metabolism, thereby potentiating the action of many pharmaceuticals. For example, proadifen inhibits the demethylation of 2-methoxyestrogens . Target (s) : aldehyde oxidase; alkanal monooxygenase, FMN- linked; aromatase, or CYP19; bacterial luciferase, or alkanal monooxygenase, FMN-linked; benzoate 4-monooxygenase; bromomethane monooxygenase7; calcium influx8; ent-copalyl-diphosphate synthase; CYPC211; cytochrome P450; diamine N- acetyltransferase; N,N-dimethylaniline demethylase; ecdysone 20- monooxygenase; ethoxyresorufin O-deethylase; flavin-containing monooxygenase, or dimethylaniline-N-oxide aldolase; glyceollin synthase; 2-hydroxyisoflavanone synthase; 25-hydroxyvitamin D3 24-monooxygenase; isopentenyl-diphosphate D-isomerase, or isopentenyl-pyrophosphate D-isomerase; ent-kaurene synthase; leukotriene B4 20-hydroxylase; (S) -limonene 3-monooxygenase; (S) -limonene 6-monooxygenase; (S) -limonene 7-monooxygenase; methane monooxygenase; monoamine oxidase; NADPH:cytochrome P450 reductase; nitric-oxide synthase, neuronal ; pentoxyresorufin O-depentylase; phenol O-methyltransferase ; progesterone 11a-monooxygenase; steroid 11b-monooxygenase ; steroid 21-monooxygenase, or CYP21A1, weakly inhibited; sterol 14-demethylase, or CYP51; styrene monooxygenase; thiol S-methyltransferase; thromboxane production; and trimethylamine-oxide aldolase.

Properties of Proadifen

Boiling point: 486.9°C (rough estimate)
Density  1.0678 (rough estimate)
refractive index  1.5614 (estimate)
pka 9.20±0.25(Predicted)
EPA Substance Registry System Benzeneacetic acid, .alpha.-phenyl-.alpha.-propyl-, 2-(diethylamino)ethyl ester (302-33-0)

Safety information for Proadifen

Computed Descriptors for Proadifen

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