Pramipexole dihydrochloride monohydrate
- CAS NO.:191217-81-9
- Empirical Formula: C10H20ClN3OS
- Molecular Weight: 265.8
- MDL number: MFCD00876894
- EINECS: 687-708-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-04 20:40:58
What is Pramipexole dihydrochloride monohydrate?
Description
Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.
Chemical properties
White or almost white, crystalline powder.
The Uses of Pramipexole dihydrochloride monohydrate
Antidepressant; antiparkinsonian; antischizophrenic; dopamine agonist.
What are the applications of Application
Pramipexole dihydrochloride monohydrate is a non-ergoline dopamine agonist
Definition
ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.
brand name
Mirapex (Boehringer Ingelheim).
General Description
Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clinical Use
Parkinson’s disease
Symptomatic treatment of restless legs
Side Effects
Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.
Drug interactions
Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.
Metabolism
Pramipexole undergoes <10% metabolism to inactive
metabolites.
More than 90% of a dose is excreted via renal tubular
secretion unchanged into the urine.
Properties of Pramipexole dihydrochloride monohydrate
Melting point: | 290 °C(dec.) |
storage temp. | 2-8°C |
solubility | Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. |
form | neat |
form | Solid |
color | White to Almost white |
Merck | 14,7705 |
InChI | InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3 |
Safety information for Pramipexole dihydrochloride monohydrate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral H336:Specific target organ toxicity,single exposure; Narcotic effects |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
Computed Descriptors for Pramipexole dihydrochloride monohydrate
InChIKey | ZTZQAWQFTIVKMU-DCFBZVEJNA-N |
SMILES | NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O |&1:5,r| |
Pramipexole dihydrochloride monohydrate manufacturer
Piramal Pharma Solutions
Alembic Pharmaceuticals Limited
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