Pramipexole dihydrochloride monohydrate

CAS NO.：191217-81-9
Empirical Formula: C10H20ClN3OS
Molecular Weight: 265.8
MDL number: MFCD00876894
EINECS: 687-708-9
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-17 16:00:36

What is Pramipexole dihydrochloride monohydrate?

Description

Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.

Chemical properties

White or almost white, crystalline powder.

The Uses of Pramipexole dihydrochloride monohydrate

Antidepressant; antiparkinsonian; antischizophrenic; dopamine agonist.

What are the applications of Application

Pramipexole dihydrochloride monohydrate is a non-ergoline dopamine agonist

Definition

ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.

brand name

Mirapex (Boehringer Ingelheim).

General Description

Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Clinical Use

Parkinson’s disease

Symptomatic treatment of restless legs

Side Effects

Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.

Drug interactions

Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.

Metabolism

Pramipexole undergoes <10% metabolism to inactive metabolites.
More than 90% of a dose is excreted via renal tubular secretion unchanged into the urine.

Properties of Pramipexole dihydrochloride monohydrate

Melting point:	290 °C(dec.)
storage temp.	2-8°C
solubility	Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
form	neat
form	Solid
color	White to Almost white
Merck	14,7705
InChI	InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3

Safety information for Pramipexole dihydrochloride monohydrate

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H336:Specific target organ toxicity,single exposure; Narcotic effects
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P270:Do not eat, drink or smoke when using this product. P271:Use only outdoors or in a well-ventilated area. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.