Potassium di-tert-butyl phosphate
Synonym(s):Phosphoric acid di-tert-butyl ester, potassium salt
- CAS NO.:33494-80-3
- Empirical Formula: C8H18KO4P
- Molecular Weight: 248.3
- MDL number: MFCD03840344
- EINECS: 619-702-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-15 19:19:13
What is Potassium di-tert-butyl phosphate?
The Uses of Potassium di-tert-butyl phosphate
Di-tert-butylphosphate Potassium Salt is a catalyst used in organic synthesis. Also used in the preparation of HIV attachment inhibitor BMS-663068.
What are the applications of Application
Utilized as an intermediate to prepare N-phosphonooxymethyl prodrugs, which increase bioavailability, and to prepare Nasicon-type phosphates (i.e., KTi2(PO4)3) used in fast ion conductors with low thermal expansion ceramics.appl
Preparation
Potassium di-tert-butyl phosphate synthesis: Di-tert-butyl phosphite (40.36 mmol) was combined with potassium bicarbonate (24.22 mmol) in 35 ml of water. The solution was stirred in an ice bath and potassium permanganate (28.25 mmole) was added in three equal portions over a period of one hour. The reaction was then allowed to continue for another half hour at room temperature. Decolorizing carbon (600 mg) was then incorporated as the reaction was heated to 60 °C for 15 min. The reaction was then vacuum filtered to remove solid magnesium dioxide. The solid was washed several times with water. The filtrate was then combined with one gram of decolorizing carbon and heated at 60°C for another twenty minutes. The solution was filtered again to give a colorless solution, which was then evaporated in vacuo to give the crude potassium di-tert-butyl phosphate salt.
Flammability and Explosibility
Non flammable
Properties of Potassium di-tert-butyl phosphate
Melting point: | 247-252°C |
storage temp. | 2-8°C |
form | Powder |
color | white |
CAS DataBase Reference | 33494-80-3 |
Safety information for Potassium di-tert-butyl phosphate
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Potassium di-tert-butyl phosphate
InChIKey | ZSWXMOQFFWMZQH-UHFFFAOYSA-M |
Abamectin manufacturer
Clarity Research Laboratory
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