POLYGODIAL
Synonym(s):(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde
- CAS NO.:6754-20-7
- Empirical Formula: C15H22O2
- Molecular Weight: 234.33
- MDL number: MFCD00238664
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is POLYGODIAL?
Description
Polygodial (6754-20-7) is a TRPA1 activator (EC50=400 nM).1?A naturally occurring drimane sesquiterpene dialdehyde found in a variety of plant species including water pepper (Polygonum hydropiper). Polygodial has been used in folk medicine for a variety of indications. Displays analgesic activity via desensitization of sensory neurons.2
The Uses of POLYGODIAL
Polygodial is a naturally occurring antifungal and antinociceptive.
What are the applications of Application
Polygodial is a naturally occurring antifungal and antinociceptive
Definition
ChEBI: Polygodial is an aldehyde.
Biochem/physiol Actions
Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.
storage
Store at -20°C
References
1) Escalera et al. (2008), TRPA1 mediates the noxious effects of natural sesquiterpene deterrents; J. Biol. Chem., 283 24136 2) Andre et al. (2004), Evidence for the involvement of vanilloid receptor in the antinociception produced by the dialdehydes unsaturated sesquiterpenes polygodial and drimanial in rats; Neuropharmacology, 46 590
Properties of POLYGODIAL
Melting point: | 57° (Barnes, Loder) |
Boiling point: | 330.7±35.0 °C(Predicted) |
alpha | D24 -131° (c = 0.96 in ethanol) |
Density | 1.084±0.06 g/cm3(Predicted) |
RTECS | QJ2850000 |
storage temp. | -20°C |
solubility | DMSO: soluble20mg/mL, clear |
form | powder |
color | white to beige |
Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
Safety information for POLYGODIAL
Computed Descriptors for POLYGODIAL
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin I Tubulysin E Tubulysin G Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Calcium Sodium Phosphosilicate IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(3,5-Di-tert-butylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 1-(4-Fluorophenyl)piperidin-2-one 1-(4-Chlorophenyl)piperidin-2-one 4,8-dibromo-5H-[1,2,3]triazolo[4',5':4,5]benzo[1,2-c][1,2,5]thiadiazole 2-(4-Bromopyridin-2-yl)acetonitrile 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 2,2-dibromopropanoate (1S)-1,5-Anhydro-1-C-[4-chloro-3-[[4-[[(3S)-tetrahydro-3-furanyl]oxy]phenyl]methyl]phenyl]-D-glucito (±)-1-Phenylethane ethane sulfonic acid ert-butyl 3-[(prop-2-yn-1-yl)amino]propanoateRelated products of tetrahydrofuran
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