2-Propenoic acid, 3,3'-(1,3-phenylene)bis-
- CAS NO.：37710-81-9
- Empirical Formula: C12H10O4
- Molecular Weight: 218.21
- MDL number: MFCD00021776
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-19 23:02:33
What is 2-Propenoic acid, 3,3'-(1,3-phenylene)bis-?
Description
CVPA (37710-81-9) is an aquaporin-1 inhibitor (IC50 = 8.1 μM) discovered by molecular docking against the extracellular domain of human aquaporin-1 followed by experimental testing in a Xenopus oocyte swelling assay.1
The Uses of 2-Propenoic acid, 3,3'-(1,3-phenylene)bis-
TC AQP1 1 is a human aquaoporin-1 (hAQP1) selective inhibitor and is considered to have therapeutic potential towards the potential treatment of glaucoma, brain edema, inflammatory pain and certain types of cancer.
storage
Store at +4°C
References
1) Seeliger et al. (2012), Discovery of novel human aquaporin-1 blockers; ACS Chem. Biol., 8 249
Properties of 2-Propenoic acid, 3,3'-(1,3-phenylene)bis-
| Boiling point: | 458.7±33.0 °C(Predicted) |
| Density | 1.358±0.06 g/cm3(Predicted) |
| storage temp. | RT |
| solubility | Soluble in DMSO (up to 25 mg/ml). |
| form | solid |
| pka | 4.07±0.10(Predicted) |
| color | White |
| Stability: | Stable for 1 year from date of pruchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
Safety information for 2-Propenoic acid, 3,3'-(1,3-phenylene)bis-
Computed Descriptors for 2-Propenoic acid, 3,3'-(1,3-phenylene)bis-
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