pipradrol hydrochloride
- CAS NO.:71-78-3
- Empirical Formula: C18H21NO.ClH
- Molecular Weight: 303.831
- EINECS: 200-764-7
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:41
What is pipradrol hydrochloride?
Description
Pipradrol is a mild stimulant containing a piperidine ring. Once used as a treatment for obesity and dementia, pipradrol is now regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Chemical properties
White Solid
Originator
Alertonic ,Adcock Ingram Ltd.
The Uses of pipradrol hydrochloride
Controlled substance (stimulant). CNS stimulant
Definition
ChEBI: Pipradrol hydrochloride is a diarylmethane.
Manufacturing Process
A mixture of 48 g (0.167 mole) of α,α-diphenyl-2-pyridinemethanol hydrochloride (Emraert et al., Ber. 72B, 1188 (1939); 74B, 714 (1940), 160 ml of ethanol, and 3 0.5 g of Adams' platinum catalyst was shaken under an initial hydrogen pressure of 60 pounds. The theoretical amount of hydrogen was absorbed in 5 hours. The reaction mixture was refluxed, diluted with enough water to dissolve all the white solid, and filtered hot from the catalyst. The filtrate was cooled and filtered; yield of 38 g of α,α-diphenyl-alpha-(2piperidyl)methanol white product melting at 308-309°C with decomposition.
A mixture of 3.5 grams (0.013 mole) of the above α,α-diphenyl-alpha-(2piperidyl)methanol, 4 g (0.05 mole) of formaldehyde (37%), and 6 grams (0.1 mole) of formic acid was refluxed for 2 days. The reaction mixture was treated with 1.3 g (0.013 mole) of conc. hydrochloric acid and vacuum distilled on the steam bath. The residue was recrystallized from butanone to give the α,αdiphenyl-alpha-(2-piperidyl)methanol hydrochloride which melted at 228229°C (dec.).
brand name
Meratran (Marion Merrell Dow).
Therapeutic Function
Central stimulant
Safety Profile
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits very toxic fumes of HCl and NOx.
Properties of pipradrol hydrochloride
Melting point: | 298-300?C |
storage temp. | Controlled Substance, -20°C Freezer |
solubility | DMSO: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 2 mg/ml; Methanol: 1 mg/ml; PBS (pH 7.2): 0.5 mg/ml |
form | A crystalline solid |
Safety information for pipradrol hydrochloride
Computed Descriptors for pipradrol hydrochloride
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