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HomeProduct name listPiperazine citrate

Piperazine citrate

Synonym(s):Citric acid sesquipiperazine salt hydrate;tri-Piperazine dicitrate

  • CAS NO.:144-29-6
  • Empirical Formula: C24H46N6O14
  • Molecular Weight: 642.65
  • MDL number: MFCD00038961
  • EINECS: 205-622-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 23:02:33
Piperazine citrate Structural

What is Piperazine citrate?

Description

Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.

Chemical properties

Piperazine citrate is a white, crystalline powder, with not more than a slight odor. It is soluble in water, and insoluble in alcohol and in ether.

The Uses of Piperazine citrate

Piperazine Citrate is an anthelmintic agent used in the treatment of parasitic infections. Also used in the reduction of blood pressure.

Indications

Used as alternative treatment for ascariasis caused by Ascaris lumbricoides (roundworm) and enterobiasis (oxyuriasis) caused by Enterobius vermicularis (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.

brand name

Antepar (GlaxoSmithKline); Bryrel (Sanofi Aventis).

Flammability and Explosibility

Not classified

Mechanism of action

Piperazine is a GABA receptor agonist. Piperzine binds directly and selectively to muscle membrane GABA receptors, presumably causing hyperpolarization of nerve endings, resulting in flaccid paralysis of the worm. While the worm is paralyzed, it is dislodged from the intestinal lumen and expelled live from the body by normal intestinal peristalsis.

Pharmacokinetics

Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.

Properties of Piperazine citrate

Melting point: 183-187℃
Boiling point: 208℃[at 101 325 Pa]
Density  0.741[at 20℃]
vapor pressure  56.928Pa
storage temp.  Inert atmosphere,Room Temperature
solubility  Soluble in DMSO
form  powder to crystal
color  White to Almost white
Water Solubility  54g/L at 24℃
Merck  14,7464
CAS DataBase Reference 144-29-6(CAS DataBase Reference)
EPA Substance Registry System Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate (3:2) (144-29-6)

Safety information for Piperazine citrate

Computed Descriptors for Piperazine citrate

Abamectin manufacturer

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