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HomeProduct name listMaropitant citrate hydrate

Maropitant citrate hydrate

Synonym(s):Cefixim Tellurite Supplement;Tellurite Cefixim Supplement

  • CAS NO.:359875-09-5
  • Empirical Formula: C38H48N2O8
  • Molecular Weight: 660.81
  • MDL number: MFCD02098080
  • EINECS: 201-069-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-09-20 17:27:21
Maropitant citrate hydrate Structural

What is Maropitant citrate hydrate?

Description

Maropitant citrate hydrate is a specific neurokinin-1 (NK-1) receptor antagonist that selectively inhibits the production of substance P, a mediator involved in signalling vomiting. Maropitant citrate was therefore originally used to treat vomiting in dogs and cats. Currently, it is also used as an adjunct to visceral analgesia in dogs and cats, and in other species such as horses and birds.

The Uses of Maropitant citrate hydrate

Anti-emetic.

Pharmacokinetics

The maximum, minimum, and average concentrations of maropitant achieved at steady state were 375.5 ± 200, 16.8 ± 7.7, and 73.5 ± 45.1 ng/ml, respectively. The terminal elimination half-life was 11.6 ± 1.4 hr, and the accumulation index was 1.3 ± 0.07. Heart rate decreased between Day 1 and Day 5 (p = .005), with three horses having heart rates of 20 beats per minute and atrioventricular block on Day 5. Pharmacokinetics of repeated maropitant administration suggests the drug could be considered for use in healthy horses.

Veterinary Drugs and Treatments

Maropitant citrate injectable solution is indicated for the prevention and treatment of acute vomiting in dogs; maropitant citrate tablets are indicated for the prevention of acute vomiting and the prevention of vomiting due to motion sickness in dogs. Both are also used extra-label in cats.

Properties of Maropitant citrate hydrate

Melting point: 153-159 °C(lit.)
Flash point: 100 °C
storage temp.  2-8°C
solubility  H2O: 1 M at 20 °C, clear, colorless
form  grit
Water Solubility  Water: 3 mg/mL (4.42 mM)
CAS DataBase Reference 359875-09-5(CAS DataBase Reference)

Safety information for Maropitant citrate hydrate

Computed Descriptors for Maropitant citrate hydrate

InChIKey XDZPFSKCXRGRIO-OHTRWSNQNA-N
SMILES C(O)(C(=O)O)(CC(=O)O)CC(=O)O.C(C1C=CC=CC=1)(C1C=CC=CC=1)[C@@H]1N2CCC(CC2)[C@@H]1NCC1C=C(C(C)(C)C)C=CC=1OC |&1:26,33,r|

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