Picotamide

Synonym(s):4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

CAS NO.：32828-81-2
Empirical Formula: C21H20N4O3
Molecular Weight: 376.41
MDL number: MFCD00866792
EINECS: 251-245-7
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-19 20:33:22

What is Picotamide?

Description

Picotamide is an unique antithrombotic agent which acts by selectively inhibiting thromboxane synthesis and blocking platelet thromboxane receptors without affecting prostaglandin synthesis. It is reported to be useful in the treatment of myocardial infarction, cerebrovascular disorders, pulmonary embolism and atherosclerosis.

Originator

Manetti-Roberts (Beecham (Italy)

The Uses of Picotamide

Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase. It is used in aptamers for targeting coagulation factor XIII and there used for treatment of thrombosis.

The Uses of Picotamide

Keratolytic.

What are the applications of Application

Picotamide is a dual inhibitor of thromboxane A2 and thromboxane A2 synthase

Definition

ChEBI: 4-methoxy-N1,N3-bis(3-pyridinylmethyl)benzene-1,3-dicarboxamide is a member of benzamides.

brand name

Plactidil

References

Modesti, et al. (1989), Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide; Eur. J. Pharmacol.. 169 85 Modesti, et al. (1991), Acute reduction of TxA2 platelet binding sites after in vivo administration of a TxA2 inhibitor; Br. J. Pharmacol.. 31 439 Ratti et al. (1998), Picotamide, an antithromboxane agent. Inhibits the migration and proliferation of arterial myocytes; Eur. J. Pharmacol. 355 77

Properties of Picotamide

Melting point:	128-131℃
Boiling point:	668.1±55.0 °C(Predicted)
Density	1.246±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 5 mg/ml with warming).
form	White solid.
pka	13.31±0.46(Predicted)
color	White
Stability:	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.

Safety information for Picotamide

GHS Hazard Statements	H303:Acute toxicity,oral
Precautionary Statement Codes	P270:Do not eat, drink or smoke when using this product. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P403:Store in a well-ventilated place.