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HomeProduct name listPHORBOL 12,13-DIBUTYRATE

PHORBOL 12,13-DIBUTYRATE

Synonym(s):PDBu;PDBu, PKC Activator II;Phorbol-12,13-dibutyrate - CAS 37558-16-0 - Calbiochem

PHORBOL 12,13-DIBUTYRATE Structural

What is PHORBOL 12,13-DIBUTYRATE?

The Uses of PHORBOL 12,13-DIBUTYRATE

Phorbol 12,13-dibutyrate has been used as a protein kinase C (PKC) activator to study its effects on human organic anion transporter 4 (hOAT4) activity. It has also been used as a PKC activator to analyze its effects on galectin-3 expression and matrix production in HL-1 cells.

What are the applications of Application

Phorbol-12,13-dibutyrate is a protein kinase C activator

Definition

ChEBI: Phorbol 12,13-dibutanoate is a phorbol ester, a butyrate ester and a tertiary alpha-hydroxy ketone.

General Description

White solid.

Reactivity Profile

PHORBOL 12,13-DIBUTYRATE may be sensitive to prolonged exposure to air, light and ambient temperatures. PHORBOL 12,13-DIBUTYRATE may also be subject to autooxidation.

Fire Hazard

The flash point of PHORBOL 12,13-DIBUTYRATE has not been determined, but PHORBOL 12,13-DIBUTYRATE is probably combustible.

Biological Activity

phorbol 12,13-dibutyrate, a phorbol ester, is an activator of pkc, including the conventional calcium-dependent subtypes (α and γ), the nonconventional calcium-independent isoforms (δ, ε, η), as well as the atypical calcium-independent and dag or phorbol ester-unresponsive subtype (ζ). pkc plays an important role in the regulation of a variety of cellular processes such as exocytosis, gene expression, cell proliferation and differentiation, as well as tumor promotion, thereby representing the major target for tumor-promoting phorbol esters and chemically unrelated tumor promoters. phorbol esters are able to replace the endogenous activator dag in the stimulation of pkc, and participate in the multistage process of tumor formation and progression.1. geiges d, meyer t, marte b, et al. activation of protein kinase c subtypes alpha, gamma, delta, epsilon, zeta, and eta by tumor-promoting and nontumor-promoting agents. biochemical pharmacology, 1997, 53(6): 865-875.2. middleton jp, khan wa, collinsworth g, et al. heterogeneity of protein kinase c-mediated rapid regulation of na/k-atpase in kidney epithelial cells. journal of biological chemistry, 1993, 268(21): 15958-15964.3. scribner jd, boutwell rk. inflammation and tumor promotion: selective protein induction in mouse skin by tumor promoters. european journal of cancer, 1972, 8(6): 617-621.

Biochem/physiol Actions

Phorbol 12,13-dibutyrate (PDBu) is a potent activator of protein kinase C (PKC). It is more hydrophilic than phorbol 12-myristate 13-acetate (PMA), which facilitates washing PDBu out of cells in tissue culture. PDBu activates endothelial nitric oxide synthase expression in primary human umbilical vein endothelial cells, which in turn correlates with PKC α and ε expression.

storage

Store at -20°C

Properties of PHORBOL 12,13-DIBUTYRATE

Boiling point: 513.95°C (rough estimate)
Density  1.1270 (rough estimate)
refractive index  1.4480 (estimate)
storage temp.  -20°C
solubility  H2O: 30 μM
form  powder
pka 11.15±0.70(Predicted)
color  clear, light yellow, film
BRN  6551234
CAS DataBase Reference 37558-16-0(CAS DataBase Reference)
EPA Substance Registry System Phorbol 12,13-dibutyrate (37558-16-0)

Safety information for PHORBOL 12,13-DIBUTYRATE

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
GHS Hazard Statements H314:Skin corrosion/irritation
H317:Sensitisation, Skin
H334:Sensitisation, respiratory
H351:Carcinogenicity
Precautionary Statement Codes P202:Do not handle until all safety precautions have been read and understood.
P260:Do not breathe dust/fume/gas/mist/vapours/spray.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for PHORBOL 12,13-DIBUTYRATE

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