1-OLEOYL-2-ACETYL-SN-GLYCEROL

Synonym(s):(9Z)-9-Octadecenoic acid (2S)-2-(acetyloxy)-3-hydroxypropyl ester;1-(cis-9-Octadecenoyl)-2-acetyl-sn-glycerol;2-Acetyl-1-oleoyl-sn-glycerol;DG(18:1(9Z)/2:0/0:0);OAG

CAS NO.：86390-77-4
Empirical Formula: C23H42O5
Molecular Weight: 398.58
MDL number: MFCD00166985
SAFETY DATA SHEET (SDS)
Update Date: 2023-07-12 08:29:14

1-OLEOYL-2-ACETYL-SN-GLYCEROL Structural

What is 1-OLEOYL-2-ACETYL-SN-GLYCEROL?

Chemical properties

Colourless to light yellow oil

The Uses of 1-OLEOYL-2-ACETYL-SN-GLYCEROL

Activator of phospholipid-dependent protein kinase C; and stimulator of secretion and aggregation in blood platelets

The Uses of 1-OLEOYL-2-ACETYL-SN-GLYCEROL

Activator of phospholipid-dependent protein kinase C; and stimulator of secretion and aggregation in blood platelets.x

The Uses of 1-OLEOYL-2-ACETYL-SN-GLYCEROL

18:1-2:0 DG (1-oleoyl-2-acetyl-sn-glycerol) has been used as a diacyl glycerol (DAG) analog to test its impact on DAG-sensitive channels in thalamocortical (TC) neurons. It may be used as an internal standard for retention time calibration in ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF MS)?for blood sample lipid quantification. It may also be used as a protein kinase C (PKC) activator in adrenal glands.

What are the applications of Application

(±)-1-Oleoyl-2-acetylglycerol is A potent and cell permeable activator of protein kinase C

What are the applications of Application

1-Oleoyl-2-acetyl-sn-glycerol (OAG) is a protein kinase C activating diacylglycerol

Definition

ChEBI: 1-Oleoyl-2-acetyl-sn-glycerol is a 1,2-diglyceride.

General Description

18:1-2:0 DG, also called 1-oleoyl-2-acetyl-sn-glycerol (OADG), is a synthetic analog of diacyl glycerol (DAG) and is membrane permeable.

Biochem/physiol Actions

1-Oleoyl-2-acetyl-sn-glycerol is a synthetic, cell permeable diacylglycerol analog. It is often used as an activator of calcium-dependent protein kinase C (PKC).

Properties of 1-OLEOYL-2-ACETYL-SN-GLYCEROL

Boiling point:	490.0±15.0 °C(Predicted)
Density	0.980±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	ethanol: 20 mg/mL
form	oil
pka	13.89±0.10(Predicted)
color	yellow
BRN	8168731
Stability:	Temperature Sensitive. This compound can rearrange to the 1,3-isomer in solution or during prolonged storage.
CAS DataBase Reference	86390-77-4(CAS DataBase Reference)

Safety information for 1-OLEOYL-2-ACETYL-SN-GLYCEROL

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H331:Acute toxicity,inhalation H336:Specific target organ toxicity,single exposure; Narcotic effects H351:Carcinogenicity H372:Specific target organ toxicity, repeated exposure H412:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P201:Obtain special instructions before use. P273:Avoid release to the environment. P302+P352:IF ON SKIN: wash with plenty of soap and water. P308+P313:IF exposed or concerned: Get medical advice/attention.