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HomeProduct name listPhenytoin sodium

Phenytoin sodium

Synonym(s):5,5-Diphenyl-2,4-imidazolidinedione;5,5-Diphenylhydantoin sodium salt;Phenytoin

  • CAS NO.:630-93-3
  • Empirical Formula: C15H13N2NaO2
  • Molecular Weight: 276.27
  • MDL number: MFCD00069674
  • EINECS: 211-148-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-12-18 14:07:02
Phenytoin sodium Structural

What is Phenytoin sodium?

Chemical properties

White or almost white, crystalline powder, slightly hygroscopic.

The Uses of Phenytoin sodium

antibacterial

The Uses of Phenytoin sodium

Antiepileptic

The Uses of Phenytoin sodium

5,5-Diphenylhydantoin sodium salt has been used:

  • in the cream preparation for treating burn wounds
  • in seizure behavior testing as an anticonvulsant in Drosophila
  • in in vivo embryo toxicity test in mouse embryonic stem cells

What are the applications of Application

5,5-Diphenylhydantoin sodium salt is a sodium channel protein inhibitor

brand name

Diphenylan (Lannett); Phenytek (Mylan); Phenytex (Watson) [Name previously used: Diphenylhydantoin Sodium.].

General Description

Phenytoin sodium, 5,5-diphenyl-2,4-imidazolidinedione, 5,5-diphenylhydantoin,diphenyl-hydantoin sodium (Dilantin), has been used fordecades in the control of grand mal types of epilepticseizure. It is structurally analogous to the barbiturates butdoes not possess their extensive sedative properties. Thecompound is available as the sodium salt. Solutions for parenteraladministration contain 40% propylene glycol and10% alcohol to dissolve the sodium salt.

Clinical Use

Phenytoin sodium’s cardiovascular effects were uncoveredduring observation of toxic manifestations of the drugin patients being treated for seizure disorders. Phenytoinsodium was found to cause bradycardia, prolong the PRinterval, and produce T-wave abnormalities on electrocardiograms.It is a class IB antiarrhythmic agent. Today,phenytoin sodium’s greatest clinical use as an antiarrhythmicdrug is in the treatment of digitalis-induced arrhythmias.34 Its action is similar to that of lidocaine. It depressesventricular automaticity produced by digitalis, without adverseintraventricular conduction. Because it also reversesthe prolongation of AV conduction by digitalis, phenytoinsodium is useful in supraventricular tachycardias caused bydigitalis intoxication.

Safety Profile

Confirmed carcinogen. Experimental teratogen. Other experimental reproductive effects. Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: anorexia, respiratory depression, nausea or vomiting, hemorrhage, dermatitis, and endocrine effects. Mutation data reported. An anticonvulsant and cardiac depressant used for the treatment of grand mal and psychomotor seizures. When heated to decomposition it emits very toxic fumes of NOx and Na2O.

Carcinogenicity

Phenytoin and its sodium salt are reasonably anticipated to be human carcinogens based on sufficient evidence from studies in experimental animals.

Solubility in water

1 g dissolves in ca. 66 ml of water. The aqueous solution is turbid unless the pH is adjusted above 11.7, which is the pH of the saturated solution. 1 g dissolves in 10.5 mL of alcohol. Practically insoluble in ether and chloroform.

Properties of Phenytoin sodium

storage temp.  Inert atmosphere,Room Temperature
solubility  aqueous base: soluble
form  Crystalline Powder
color  White to almost white
Merck  14,7322
Stability: Hygroscopic
CAS DataBase Reference 630-93-3(CAS DataBase Reference)
EPA Substance Registry System Diphenylhydantoin sodium (630-93-3)

Safety information for Phenytoin sodium

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
ghs
Health Hazard
GHS08
GHS Hazard Statements H302:Acute toxicity,oral
H317:Sensitisation, Skin
H361:Reproductive toxicity
Precautionary Statement Codes P201:Obtain special instructions before use.
P202:Do not handle until all safety precautions have been read and understood.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P308+P313:IF exposed or concerned: Get medical advice/attention.

Computed Descriptors for Phenytoin sodium

InChIKey FJPYVLNWWICYDW-UHFFFAOYSA-M

Phenytoin sodium manufacturer

JPN Pharma Pvt Ltd

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Phone:+919833233531
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Macleods Pharmaceuticals Limited

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Unichem Laboratories Ltd

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Orchid Pharma Ltd. (Formerly Known as Orchid Chemicals and Pharmaceuticals Ltd.)

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Harman Finochem Ltd

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Global Calcium Pvt Ltd

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Swati Spentose Pvt Ltd

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