PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
Synonym(s):2,2ʹ-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4;2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol);B10;MT4;p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem
- CAS NO.:1638-41-1
- Empirical Formula: C12H4Cl6O4S
- Molecular Weight: 456.94
- MDL number: MFCD00397032
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-14 17:34:47
What is PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-?
The Uses of PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor.
The Uses of PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
p38 MAP Kinase Inhibitor IV has been used for blocking p38α kinase activation in order to examine if HOXB7 is involved in the regulation of migration and proliferation process via AKT/MAPK signaling.
What are the applications of Application
p38 MAP Kinase Inhibitor IV is an ATP-competitive p38α/β MAPK inhibitor
General Description
A cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 μM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM respective inhibitor).
Biochem/physiol Actions
p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.
Properties of PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
Melting point: | 244-245 °C(Solv: ethyl acetate (141-78-6)) |
Boiling point: | 590.0±50.0 °C(Predicted) |
Density | 1.854±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | DMSO: soluble5mg/mL, clear (warmed) |
pka | 2.43±0.50(Predicted) |
form | powder |
color | white to beige |
Safety information for PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
Computed Descriptors for PHENOL,2,2'-SULFONYLBIS[3,4,6-TRICHLORO]-
New Products
Tubulysin D Tubulysin C (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin M 2,2-diethoxyethanethioamide 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 3-N-BOC-(S)-AMINO BUTYRONITRILE 3-Aminocyclobutanone hydrochloride 2,2-Difluoropropanol tetrahydro-4-methyl-2H-pyran 4-(Benzyloxy)-3-bromophenylacetic Acid 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
p38 MAP Kinase Inhibitor IV >95% CAS 1638-41-1View Details
1638-41-1 -
p38 MAP Kinase Inhibitor IV CAS 1638-41-1View Details
1638-41-1 -
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8