Pentafluoro-1-propanol

Synonym(s):PFPOH

CAS NO.：422-05-9
Empirical Formula: C3H3F5O
Molecular Weight: 150.05
MDL number: MFCD00004673
EINECS: 207-012-7
SAFETY DATA SHEET (SDS)
Update Date: 2023-04-27 16:27:43

What is Pentafluoro-1-propanol?

Chemical properties

clear colorless to slightly yellow liquid

The Uses of Pentafluoro-1-propanol

2,2,3,3,3-Pentafluoro-1-Propanol is a useful reagent for the preparation of (oxoindolinyl)ethers/benzoates via photochemical O-H functionalization reactions of cyclic diazoamides.

The Uses of Pentafluoro-1-propanol

2,2,3,3,3-Pentafluoro-1-propanol has been used:

as derivatization reagent in detection of unlabeled and ¹⁵N₂ -labeled L-tryptophan, L-kynurenine, serotonin and quinolinic acid in human and rat plasma by GC-MS
as derivatization reagent in simultaneous analysis of cocaine, cocaethylene and their possible metabolic and pyrolytic products in blood, urine and muscle by GC-MS
preparation of trifluoromethyl ynamines which, in turn, converted aldehydes to α-trifluoromethyl-α,β-unsaturated amides
to generate fluorinated α-keto ethers with alkenes and has wide applications in the expanding fluorous research area

General Description

2,2,3,3,3-Pentafluoro-1-propanol is an alternative cleaning agent for chlorofluorocarbon.

Safety Profile

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of Fí.

Purification Methods

Shake the alcohol with alumina for 24hours, dry with anhydrous K2CO3, and distil it, collect the middle fraction (b 80-81o) and redistil it. [Beilstein 1 IV 1438.]

Properties of Pentafluoro-1-propanol

Boiling point:	80 °C748 mm Hg(lit.)
Density	1.505 g/mL at 25 °C(lit.)
vapor pressure	62.055-324.857hPa at 24.93-54.78℃
refractive index	n20/D 1.288(lit.)
Flash point:	80-81°C
storage temp.	Flammables area
form	Powder, Crystals and/or Chunks
pka	12.45±0.10(Predicted)
Specific Gravity	1.509
color	White to off-white to light yellow
Water Solubility	Soluble in water.21.9 g/L at 25°C
BRN	1743133
CAS DataBase Reference	422-05-9(CAS DataBase Reference)
NIST Chemistry Reference	2,2,3,3,3-Pentafluoro-1-propanol(422-05-9)
EPA Substance Registry System	1-Propanol, 2,2,3,3,3-pentafluoro- (422-05-9)

Safety information for Pentafluoro-1-propanol

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.