PD318088
- CAS NO.:391210-00-7
- Empirical Formula: C16H13BrF3IN2O4
- Molecular Weight: 561.09
- MDL number: MFCD18384973
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:55:00
What is PD318088?
What are the applications of Application
PD318088 is a small molecule inhibitor of MEK-1 and MEK-2
Biological Activity
pd318088 is an allosteric and non-atp competitive mek1/2 inhibitor.pd318088 is an analog of pd184352, which means it might have important anti-proliferative activity against cancer cells, although no functional study of pd318088 is currently available. pd318088 binds simultaneously with atp in a region of the mek1 active site that is adjacent to the atp-binding site. formation of the ternary complexes with pd318088 and mgatp results in moderate increases (to 140 nm) for the kd monomer-dimer for both mek1 and mek2. pd318088 and mgatp together increase the dimerization disassociation constant for mek1 and mek2 slightly from ~75 nm to ~140 nm [1].pd318088 is a biarylamine compound co-crystallized with mek. g8935 occupies the unique pocket adjacent to atp binding site and is uperimposed with pd318088 .pd318088 averts to use the pocket formed by ile216, phe209, arg189, and asp190. [2]
References
1. ohren jf1, chen h, pavlovsky a et al. structures of human map kinase kinase 1 (mek1) and mek2 describe novel noncompetitive kinase inhibition. nat struct mol biol. 2004 dec;11(12):1192-7. epub 2004 nov 14.2. han s, zhou v, pan s et al. identification of coumarin derivatives as a novel class of allosteric mek1 inhibitors. bioorg med chem lett. 2005 dec 15;15(24):5467-73. epub 2005 sep 30.
Properties of PD318088
Density | 1.993 |
storage temp. | Store at -20°C |
solubility | ≥28.05 mg/mL in DMSO; insoluble in H2O; ≥7.36 mg/mL in EtOH with ultrasonic |
form | solid |
pka | 13.42±0.20(Predicted) |
color | Light yellow to yellow |
Safety information for PD318088
Computed Descriptors for PD318088
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Ivermectin EP Impurity B Rimegepant Impurity 3 Tubulysin A Tubulysin E (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin H 2,2-diethoxyethanethioamide Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Fuel shell 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 3,3,6,6-Tetramethylcyclohexane-1,2-dione Methyl 4-amino-3-(pyrrolidin-1-yl)benzoate Methyl 4-amino-3-(piperidin-1-yl)benzoate 2-Ethoxy-4-nitrobenzoic acid 2-(4-Bromopyridin-2-yl)acetonitrile 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 3-(4-bromo-1H-pyrazol-1-yl)-N,N-dimethylpropanamide 6-bromo-4-methyl-2-propyl-1H-1,3-benzodiazoleRelated products of tetrahydrofuran
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