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HomeProduct name listCilnidipine

Cilnidipine

Synonym(s):1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester;FRC 8653

  • CAS NO.:132203-70-4
  • Empirical Formula: C27H28N2O7
  • Molecular Weight: 492.52
  • MDL number: MFCD00865853
  • EINECS: 634-350-6
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-08 21:13:59
Cilnidipine Structural

What is Cilnidipine?

Description

Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.

Description

Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats. It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg. Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.

Chemical properties

Yellow Crystalline Solid

Originator

Fujirebio (Japan)

The Uses of Cilnidipine

Cilnidipine has been used:

  • in cell viability assay of pheochromocytoma (nPC12) cells
  • in photoirradiation and photodegradation studies
  • to understand effect on albuminuria in diabetic nephropathy

The Uses of Cilnidipine

antihypertensive;dihydropyridine calcium channel blocker

The Uses of Cilnidipine

A dihydropyridine calcium channel blocker.

What are the applications of Application

Cilnidipine is an L-/N-type calcium channel protein inhibitor and blocker

Definition

ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.

brand name

Cinalong;Siscard;Atelec

Biological Activity

Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.

Biochem/physiol Actions

Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.

storage

+4°C

Properties of Cilnidipine

Melting point: 97-99°C
Boiling point: 652.6±55.0 °C(Predicted)
Density  1.240±0.06 g/cm3(Predicted)
storage temp.  Keep in dark place,Sealed in dry,Room Temperature
solubility  H2O: ≤2mg/mL
form  powder
pka 2.61±0.70(Predicted)
color  light yellow
Merck  14,2275
CAS DataBase Reference 132203-70-4(CAS DataBase Reference)

Safety information for Cilnidipine

Signal word Danger
Pictogram(s)
ghs
Corrosion
Corrosives
GHS05
GHS Hazard Statements H318:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Cilnidipine

InChIKey KJEBULYHNRNJTE-DHZHZOJOSA-N

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