Cilnidipine
Synonym(s):1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl (2E)-3-phenyl-2-propenyl ester;FRC 8653
- CAS NO.:132203-70-4
- Empirical Formula: C27H28N2O7
- Molecular Weight: 492.52
- MDL number: MFCD00865853
- EINECS: 634-350-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 21:13:59
What is Cilnidipine?
Description
Cilnidipine is a dihydropyridine calcium antagonist introduced for the treatment of essential and severe hypertension and hypertension associated with renopathy. Cilnidipine has been demonstrated to exert a potent vasodilating effect by blocking calcium influx via dihydropyridine-sensitive, voltage-dependent calcium channels. Compared to nifedipine and nicardipine, cilnidipine is superior, especially for long-term treatment, due to its characteristics of slow onset and long duration with less cardiodepressant activity. Cilnidipine is reportedly well tolerated with low toxicity. It may also be useful in ischemic heart disease.
Description
Cilnidipine is a dihydropyridine calcium channel blocker that blocks L- and N-type high-voltage-activated calcium currents in rat hippocampal CA1 pyramidal neurons when used at a concentration of 10 μM. Cilnidipine (3 mg/kg) reduces the pressor response to acute cold stress, as well as mean blood pressure, in spontaneously hypertensive rats. It dose-dependently reduces mean blood pressure and cerebral vascular resistance without affecting cerebral blood flow in anesthetized rats at doses ranging from 3-100 μg/kg. Cilnidipine (100 μg/kg, i.p.) reduces cerebral infarction area in a rat model of focal brain ischemia.
Chemical properties
Yellow Crystalline Solid
Originator
Fujirebio (Japan)
The Uses of Cilnidipine
Cilnidipine has been used:
- in cell viability assay of pheochromocytoma (nPC12) cells
- in photoirradiation and photodegradation studies
- to understand effect on albuminuria in diabetic nephropathy
The Uses of Cilnidipine
antihypertensive;dihydropyridine calcium channel blocker
The Uses of Cilnidipine
A dihydropyridine calcium channel blocker.
What are the applications of Application
Cilnidipine is an L-/N-type calcium channel protein inhibitor and blocker
Definition
ChEBI: A diesterified 1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium channel blocker, it is used as an antihypertensive.
brand name
Cinalong;Siscard;Atelec
Biological Activity
Dual L- and N-type calcium channel blocker that displays antihypertensive, sympatholytic and neuroprotective activity. Lowers mean blood pressure and reduces the size of cerebral infarction in the rat model of focal brain ischemia.
Biochem/physiol Actions
Cilnidipine is a slow-acting Ca2+ channel blocker; antihypertensive; vasodilator; dual blocker of L-type voltage-gated Ca2+ channels in vascular smooth muscle and N-type Ca2+ channels in sympathetic nerve terminals that supply blood vessels. Cilnidipine may offer an advantage over nifedipine as the long term intake of the latter has been linked to increased risk of myocardial infarction and mortality in patients with coronary artery disease. Cilnidipine lowers blood pressure, but has less effect on sympathetic activity. Unlike nifedipine, cilnidipine does not inhibit PKC.
storage
+4°C
Properties of Cilnidipine
Melting point: | 97-99°C |
Boiling point: | 652.6±55.0 °C(Predicted) |
Density | 1.240±0.06 g/cm3(Predicted) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | H2O: ≤2mg/mL |
form | powder |
pka | 2.61±0.70(Predicted) |
color | light yellow |
Merck | 14,2275 |
CAS DataBase Reference | 132203-70-4(CAS DataBase Reference) |
Safety information for Cilnidipine
Signal word | Danger |
Pictogram(s) |
Corrosion Corrosives GHS05 |
GHS Hazard Statements |
H318:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cilnidipine
InChIKey | KJEBULYHNRNJTE-DHZHZOJOSA-N |
Abamectin manufacturer
Dayaram Pharma Chem
JR Corporation
Ralington Pharma
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