Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listParoxetine hydrochloride

Paroxetine hydrochloride

Synonym(s):(3S-trans)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)piperidine hydrochloride hemihydrate;Paroxetine hydrochloride hemihydrate

  • CAS NO.:78246-49-8
  • Empirical Formula: C19H21ClFNO3
  • Molecular Weight: 365.83
  • MDL number: MFCD00797405
  • EINECS: 616-601-1
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-04 13:44:46
Paroxetine hydrochloride Structural

What is Paroxetine hydrochloride?

Chemical properties

White Crystalline Powder

Originator

Paxil, SmithKline Beecham ,France

The Uses of Paroxetine hydrochloride

A selective serotonin reuptake inhibitor. Used as an antidepressant

The Uses of Paroxetine hydrochloride

Paroxetine is an antidepressant drug of the SSRI type

What are the applications of Application

Paroxetine HCl is a highly potent and selective serotonin (5-HT) uptake inhibitor

Definition

ChEBI: Paroxetine hydrochloride is the hydrochloride salt of paroxetine. It is an antidepressant drug. It has a role as an antidepressant, an anxiolytic drug, a hepatotoxic agent, a P450 inhibitor and a serotonin uptake inhibitor. It contains a paroxetinium(1+).

Manufacturing Process

251 g of methyl-4-(4-fluorophenyl)-N-methyl-nipecotinate, 8 g of sodium methoxide and 500 ml benzene were refluxed for 2 h. The benzene solution was washed with cold water and evaporated to give the pure α-ester which was dissolved in a mixture of 320 ml of water and 450 ml concentrated hydrochloric acid. The solution was slowly distilled to remove methanol and finally evaporated to dryness in vacuo.
400 ml thionyl chloride were added in small portions to the solid. The mixture was allowed to stand for 3 h at room temperature and was then evaporated to dryness in vacuo with tetrachloroethane giving methyl-4-(4-fluorophenyl)-Nmethylnipecotic acid chloride. The acid chloride was added in small portions to a solution of 160 g (-)-menthol in 800 ml pyridine at a temperature of 0°-5°C. The mixture was allowed to stand at room temperature to the next day. Ice water and 50% sodium hydroxide were added, and the mixture was extracted with ether. The ether was dried with anhydrous magnesium sulphate, filtered and evaporated. Distillation in vacuo gave the menthol ester in a yield of 7580%. Boiling point at 0.05 mm Hg was 165°-170°C.
Racemic 4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine (50 g) was dissolved in a mixture of 21.6 ml of concentrated sulfuric acid and 50 ml of water. To the solution were added 25 ml of concentrated hydrochloric acid and 22.4 ml of 37% formaldehyde solution. The mixture was refluxed for 5 h, cooled, and 125 ml of concentrated ammonia were added. The mixture was extracted with 50 ml of toluene. Drying of the toluene solution and distillation gave 38 g of 4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine with boiling point 110°-120°C at 0.1 mm Hg.
13 g of the racemic compound and 22 g of (-)-dibenzoyltartaric acid were dissolved in 105 ml of hot methanol. On cooling, 9 g of salt of (-)-4-(4fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6-tetrahydropyridine crystallized. Melting point 167°-168°C.
38 g of (-)-4-(4-fluorophenyl)-3-hydroxymethyl-1-methyl-1,2,3,6tetrahydropyridine were dissolved in 350 ml of 99% ethanol, 5 g of 5% palladium on carbon were added, and the mixture was treated with hydrogen until 4500 ml were absorbed. The catalyst was filtered off, and the solution was evaporated to yield 37.5 g of (+)-b-4-(4-fluorophenyl)-3-hydroxymethyl1-methylpiperidine.
To a solution of sodium in methanol (125 ml) were added 3,4methylenedioxyphenol (29 g) and the (+)-b-4-(4-fluorophenyl)-3hydroxymethyl-1-methylpiperidine (37,5 g). The mixture was stirred and refluxed. After removal of the solvent in vacuo, the evaporation residue was poured into a mixture of ice (150 g), water (150 ml), and ether (200 ml). The ether layer was separated, and the aqueous layer was extracted with ether. The combined ether solutions were washed with water and dried with anhydrous magnesium sulphate, and the ether was evaporated. The residue was triturated with 200 ml of 99% ethanol and 11.5 ml of concentrated hydrochloric acid, yielding 30 g of (-)-b-4-(4-fluorophenyl-3-(1,3-benzdioxolyl(3)-oxymethyl)-1-methylpiperidine, hydrochloride were obtained. Melting point 202°C.

brand name

Paxil (GlaxoSmithKline).

Therapeutic Function

Antidepressant

Biological Activity

paroxetine hydrochloride is a antidepressant agents known as selective serotonin-reuptake inhibitors (ssris).paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake. paroxetine likely inhibits the reuptake of serotonin at the

storage

Room temperature

Properties of Paroxetine hydrochloride

Melting point: 129-131°C
storage temp.  2-8°C
solubility  insoluble in H2O; ≥17.8 mg/mL in EtOH; ≥18.29 mg/mL in DMSO
form  neat
form  Solid
color  White to off-white
CAS DataBase Reference 78246-49-8(CAS DataBase Reference)

Safety information for Paroxetine hydrochloride

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Paroxetine hydrochloride

Abamectin manufacturer

Apotex Pharmachem India Pvt Ltd

1Y
Phone:+91-8022891000
product: 78246-49-8 Paroxetine hydrochloride 98%
Inquiry

Enal Drugs Pvt Ltd

1Y
Phone:+91-4044753636
product: Paroxetine hydrochloride 98%
Inquiry

Sun Pharmaceutical Industries Ltd

1Y
Phone:+91-2243244324
product: Paroxetine hydrochloride 98%
Inquiry

Ralington Pharma

1Y
Phone:+91-9687771722
Whatsapp: +91- 9687771722
product: Paroxetine hydrochloride 78246-49-8 98%
Inquiry

Abhilasha Pharma Pvt Ltd

1Y
Phone:+91-9227135395
Whatsapp: +91-9227135395
product: 78246-49-8 Paroxetine hydrochloride 99%
Inquiry

Mylan Laboratories Ltd

1Y
Phone:+914030866666
product: 78246-49-8 98%
Inquiry

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.